Tanabe Seiyaku Company, Limited

Toshikazu Miyagishima

Mamoru Matsumoto

Yuzo Matsuoka

Ikuo Iijima

Yutaka Saiga

Totaro Yamaguchi

Satoshi Ohshima

Mitsuyoshi Wagatsuma

Masahiko Seto

Mitsutaka Kawazu

Novel tetrahydro-.beta.-carboline derivatives of the formula: ##STR1## wherein R.sup.1 is carboxyl, a lower alkoxycarbonyl, carbamoyl, an N,N-di-lower alkylcarbamoyl, an N-(phenyl-substituted lower alkylidenamino)carbamoyl, a [N,N-di(lower alkyl)amino]-lower alkyl, or a nitrogen-containing monocyclic heterocyclic group;

Tetrahydro-.beta.-carboline derivatives and treatment of liver diseases

Tetrahydro-.beta.-carboline derivative of the formula: ##STR1## wherein R.sup.2 is lower alkyl, and either (A)

Tetrahydro-.beta.-carboline derivatives

Tetrahydro-.beta.-carboline derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkyl group, a cycloalkyl group, phenyl group or a hydroxy-substituted lower alkyl group, R.sup.2 is hydrogen atom, an alkyl group, or a group of the formula: --(CH.sub.2).sub.m Y, Y is thienyl or a substituted or unsubstituted phenyl group, and m and n are an integer of 1 or 2, which have excellent alleviating, curing and preventing hepatic damages and are useful as a therapeutic or prophylactic agent for hepatic diseases, and a process for the preparation of said compounds.

Tetrahydro-.beta.-carboline dithioic acid derivatives and treatment of

A compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is a group of the formula: --CO-CH(NH.sub.2)-CH.sub.2 COR.sup.3 or --COCH.sub.2 -CH(NH.sub.2)-COR.sup.3, and R.sup.3 is selected from the group consisting of hydroxy, lower alkylamino, di-lower alkylamino, lower alkoxy and hydroxy-lower alkylamino, or R.sup.3 is amino when R.sup.2 is hydroxy. Several methods of preparing the compound [I] are also disclosed. The compound [I] and a pharmaceutically acceptable salt thereof are useful as antimicrobial agents.

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Wako, Japan

Toshikazu Miyagishima