Kowa Company Limited

Asahi Kasei Kogyo Kabushiki Kaisha

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Toshihito Mori

Kazuhiro Kamiya

Akio Iwasaki

Isamu Watanabe

Toshimi Mizoguchi

Takeo Deushi

Masahito Nakayama

Hisakatsu Ito

Takashi Yamaguchi

Shigeru Kimura

Sohei Tanabe

Takeshi Oda

Takafumi Kunieda

Hisakatsu Itoh

Akira Murakami

Masao Okuchi

Takahiro Torii

Hamao Umezawa

Sumio Umezawa

Tsutomu Tsuchiya

Hideo Yoshizaki

Akio Hasegawa

Nobuo Yokoo

Masahoto Nakayama

An aminoglycoside compound represented by the following formula (I) ##STR1## wherein one of R.sub.1 and R.sub.2 represents a hydrogen atom, and the other represents a methyl group,

Aminoglycoside compounds, processes for production thereof, and

An aminoglycoside compound represented by the following formula (1) ##STR1## wherein R.sub.1 and R.sub.2 are different from each other and each represents a hydrogen atom or a methyl group,

Aminoglycoside compounds

A novel antibiotic designated as KA-6643 and having the formula, ##STR1## wherein R is hydrogen or --SO.sub.3 H.

.beta.-Lactam antibiotics

A process for producing an antibiotic, which comprises cultivating an antibiotic KA-6606-producing strain of the genus Saccharopolyspora in a nutrient culture medium, isolating an antibiotic KA-6606-containing substance from the culture broth, and separating from the resulting antibiotic KA-6606-containing substance at least one antibiotic selected from the group consisting of antibiotic KA-6606 VII, KA-6606 VIII, KA-6606 IX, KA-6606 X, KA-6606 XI, KA-6606 XII, KA-6606 XIII, KA-6606 XIV, KA-6606 XV, KA-6606 XVI and KA-6606 XVII; and novel antibiotics KA-6606 XII, XIII and XV to XVII.

Antibiotics KA-6606 XII, XIII, XV, XVI and XVII

A plasminogen activator obtained from a tissue cultured liquor of human normal tissue derived cells, e.g., human embryonic derived cells, human placenta derived cells etc., and having the following properties:

Purified plasminogen activator, process for its production and

A compound of the following formula ##STR1## wherein each of R.sub.1, R.sub.2 and R.sub.3 represents H or CH.sub.3, R.sub.4 represents H or C.sub.2 -C.sub.4 acyl substituted at the 2-, 3- or 4-position by an amino group, and Y represents ##STR2## provided that R.sub.1 and R.sub.2 are not CH.sub.3 at the same time, and an acid addition salt thereof; and a process for the production thereof.

2'-N-.beta.-Lysyl) aminoglycosides

An aminoglycoside represented by the following formula (1) ##STR1## wherein each of R.sub.1 and R.sub.2 represents a hydrogen atom or a methyl group, R.sub.3 represents a hydrogen atom or an aminoacyl group, R.sub.4 represents a hydrogen atom or a hydroxyl or methoxy group, and R.sub.5 represents a hydrogen atom or a hydroxyl group, or a pharmaceutically acceptable acid addition salt thereof, a process for the production thereof and a pharmaceutical use thereof.

2'-Deamino aminoglycosides and composition thereof

A-KA-6643-series antibiotic comprising at least one substance represented by any of the following formulae, or a salt or ester thereof: ##STR1## is effectively useful as an antibacterial and .beta.-lactamase inhibiting agent.

KA-6643-Series antibiotics, process for producing same and medical

An aminoglycoside compound of the following formula ##STR1## wherein one of R.sub.1 and R.sub.2 represents a hydrogen atom and the other, a methyl group, R.sub.3 represents a hydrogen atom or an amino acyl group having 2 to 5 carbon atoms, R.sub.4 represents a lower alkyl group substituted by one or two substituents selected from the class consisting of hydroxy and amino groups, or a hexopyranosyl group whose hydroxy groups may be substituted by amino groups, and a pharmaceutically acceptable acid addition salt thereof; and an antibiotic composition comprising said compound and its pharmaceutically acceptable acid addition salt.

Aminoglycosides and use thereof

A process for producing an antibiotic, which comprises cultivating an antibiotic KA-6606-producing strain of an genus Saccharopolyspora in a nutrient culture medium, isolating the antibiotic KA-6606-containing substance from the culture broth, and separating from the resulting antibiotic KA-6606-containing substance at least one antibiotic selected from the group consisting of antibiotic KA-6606 VII, KA-6606 VIII, KA-6606 IX, KIA-6606 X, KA-6606 XI, KA-6606 XII, KA-6606 XIII, KA-6606 XIV, KA-6606 XV, KIA-6606 XVI and KA-6606 XVII; and novel antibiotics KA-6606 XII, XIII and XV to XVII.

Process for production of antibiotics and novel antibiotics produced

An antibiotic KA-6643-A or a salt thereof having the formula: ##STR1## is produced by a process comprising the step of hydrolyzing an antibiotic KA-6643-B of the formula: ##STR2##

Process for producing an antibiotic

Novel antibiotics of the following structure ##STR1## wherein R represents a moiety selected from the group consisting of hydrogen, --COCH.sub.2 NH.sub.2, --COCH.sub.2 NHCONH.sub.2 and --COCH.sub.2 NHCHO; process for preparation thereof; and biologically pure culture for use therein.

Biologically pure culture

A compound of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 are different and each represents a hydrogen atom or a methyl group, R.sub.3 represents a hydrogen atom, or a glycyl group which may be substituted, and the symbol  between the carbon atoms at the 5- and 6- positions represents a single or double bond, and an acid addition salt thereof; and its antibiotic use.

Ka-6606 Aminoglycosides antibiotics and compositions thereof

An antibiotic substance KA-7038 selected from the group consisting of the compounds having formulae I to VII described in claim 1, mixtures thereof and acid addition salts thereof; an antibiotic composition composed of (i) antibiotically effective amount of aforesaid antibiotic substance KA-7038, and (ii) a pharmaceutically acceptable diluent or carrier. The antibiotic substance KA-7038 can be produced by cultivating an antibiotic substance KA-7038-producing strain belonging to genus Streptomyces, for example Streptomyces sp. KC-7038, and isolating the antibiotic substance KA-7038 from the culture broth.

Growing community of inventors

Higashimurayama, Japan

Toshihito Mori