Taisho Pharmaceutical Co., Ltd.

Other

Nissan Chemical Industries Limited

Nihon Nohyaku Co., Ltd.

Toshihito Kumagai

Atsuro Nakazato

Kazuyuki Tomisawa

Taketoshi Okubo

Shigeyuki Chaki

Masanori Yoshida

Kazunari Sakagami

Masashi Nagamine

Makoto Gotoh

Yoshinori Sekiguchi

Toshio Nakamura

Kazuya Kameo

Takeo Taguchi

Koumei Ohta

Yuri Amada

Hideo Tanaka

Tsuyoshi Shibata

Takaaki Ishii

Masato Hayashi

Yutaka Kawashima

Takanori Shimizu

Shigeru Okuyama

Takeshi Kuwada

Kumi Abe

Xiang-Min Sun

Hisaya Wada

Shigetada Sasako

Tomoko Ishizaka

Kosuke Kanuma

Yoshihiro Kimura

Izumi Aibe

Takayuki Nagatsuka

Hisanako Ito

Kuniaki Kondoh

Katsuo Hatayama, Deceased

Tomoki Miyazawa

Noriaki Murase

Yuri Fujisawa

Hisahide Tanimoto

Taketoshi Okubu

Hisanaka Ito

A process for producing a 3-alkoxy-2-amino-6-fluoro bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative represented by the formula (I) or a salt thereof, which includes converting a compound represented by the formula (VI) or a salt thereof to the compound represented by the formula (I) or a salt thereof. 

Process for producing 3-alkoxy-2-amino-6-fluorobicyclo [3.1.0] hexane-2,6-dicarboxylic acid derivative and intermediate thereof

Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MCreceptor antagonistic effect.

Aminopyrrolidine compound

An object of the present invention is to provide a cyclic amine compound which has a potent inhibitory effect on the binding of &#x3b1;2C-adrenoceptor and is useful in preventing and treating disorders attributable to &#x3b1;2C-adrenoceptor. The above-described object is solved by the following cyclic amine compound, etc., 

Cyclic amine compound

A 1,3-dihydro-2H-indol-2-one derivative expressed by Formula 1 (wherein Ris a halogen atom, a Cto Calkyl group, etc., and Ris a hydrogen atom, a halogen atom, etc., or Ris in the 6-position of the indol-2-one and Rand Rjoin together to form a Cto Calkylene group, Ris a halogen atom, a hydroxyl group, etc., and Ris a hydrogen atom, a halogen atom, a Cto Calkyl group, etc., or Ris in the 3-position of the phenyl and Rand Rjoin together to form a methylenedioxy group, Ris a hydrogen atom or a fluorine atom, Ris an ethylamino group, a dimethylamino group, etc., Ris a Cto Calkoxy group, and Ris a Cto Calkoxy group), or a pharmaceutically acceptable salt of this derivative. This is a novel compound that has antagonistic activity against an aruginine-vasopressin V1receptor.

1,3-dihydro-2H-indol-2-one derivative

A tetrahydropyridino or piperidino heterocyclic derivative represented by the formula [I]:A-Het [I]has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

Tetrahydropyridino or piperidino heterocyclic derivatives

Carbamoyl tetrahydropyridine derivatives represented by the formula:[in the formula, Rand Rare identical or different, and each represents a hydrogen atom, a C-Calkyl group, or the like; Y&#x2014;Yrepresents (R)C&#x2550;C(R), (R)C&#x2550;N, N&#x2550;N, (R) N&#x2014;CO, or N&#x2550;C(R); X, X, and Xare identical or different, and each represents a hydrogen atom, a halogen atom, or the like; R, R, R, and Rare identical or different, and each represents a hydrogen atom or an alkyl group; Rrepresents a hydrogen atom, a C-Calkyl group, or the like; and Rrepresents a hydrogen atom or a carbamoyl group] or a pharmaceutically acceptable salt thereof, and intermediates for the preparation thereof are provided. The derivatives described above are effective for diseases which are believed to involve CRF.

Carbamoyl tetrahydropyridine derivatives

A tetrahydropyridino or piperidino heterocyclic derivative represented by the formula [I]:A-Het &#x2003;&#x2003;[I]has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

Tetrahydropyridino or piperidino heterocylic derivatives

Intermediate and process for producing fluorinated carboxylic acid derivative from the same

Arylpiperidine derivatives and use thereof

Dicarboxylic acid derivatives

Carboxylic acid derivatives and process for producing the same

Carboxylic acid derivatives and process for producing same

Intermediates and process for producing fluorine-containing amino acid compound by using the same

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Tokyo, Japan

Toshihito Kumagai