Forsyth Dental Infirmary for Children

Other

Harvard College

Toshihisa Kawai

David J Mooney

Roger Warren Sands

Philip P Stashenko

Kenneth I Kohn

Eduardo Alexandre Barros E Silva

Kazuhisa Ohara

Mikihito Kajiya

Kimihiro Sato

Yoshitaka Hosokawa

Eduardo Alexandra Barros E Silva

Yoshiaka Hosokawa

Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease.

Programming of cells for tolerogenic therapies

A composition for treating inflammation and pain, including a hydrogen-generating compound in an amount that increases the amount of hydrogen in an individual and has an anti-inflammatory effect. A composition for treating inflammation and pain, including synergistically effective amounts of pregabalin and lactulose. A method of treating inflammation and pain, by administering a composition comprising a hydrogen-generating compound to an individual in an amount that increases the amount of hydrogen in the individual and has an anti-inflammatory effect.

Anti-inflammatory compounds in combination with hydrogen for the treatment of inflammation

A method of treating inflammation in a subject by administering a composition including hydrogen, releasing hydrogen in the subject, suppressing mitogen-activated protein kinase (MAPK) phosphorylation and upregulating expression of MKP-1, and down-regulating inflammatory responses of monocyte lineage cells.

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The present invention relates to oral antibacterial compositions comprising trihydroxybenzoate derivatives, e.g., useful for the treatment of gum diseases (e.g., gingivitis or periodontitis) and to methods of using such compositions.

Antibacterial compositions

Growing community of inventors

Brookline, MA, United States of America

Toshihisa Kawai