Ajinomoto Co., Ltd.

Toshihisa Kato

Shinichi Kishimoto

Tadashi Takemoto

So Abe

Hideo Takeda

Mikiya Kano

Naohiko Yasuda

Masahiko Kurauchi

Nobuyoshi Kitamura

Hisao Iwagami

Shinji Fujita

Takehiko Kataoka

Akihiko Yasaki

Ken-ichi Mori

Satoshi Kumon

Naoko Sugiyama

Sou Abe

Kimiyasu Sakamoto

Masahiko Oshimura

A ruminant feed additive composition containing (A) lysine magnesium phosphate, (B) magnesium oxide, (C) a binder and (D) water, said water content being between 5 and 15% by weight, and processes for producing the composition.

Ruminant feed additive composition and process for producing the same

A method for the solid-liquid separation of a suspension of .alpha.-L-aspartyl-L-phenylalanine methyl ester (.alpha.-APM) or its hydrochloride salt (.alpha.-APM.HCl), wherein an aqueous suspension of .alpha.-L-aspartyl-L-phenylalanine methyl ester or its hydrochloride salt is subjected to continuous separation by vacuum filtration.

Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester or

In crystallizing .alpha.-APM from a water solution or a mixed solvent solution of water and a lower alcohol in a crystallizer, the pressure in the crystallizer is held at not higher than atmospheric pressure, a water or water/alcohol mixed solution of .alpha.-APM is fed into the crystallizer with stirring so that the solvent is vaporized, and the crystallization solution is cooled and crystallized by the latent heat of vaporization or is heated so as to prevent supercooling.

Method of crystallizing .alpha.-L-aspartyl-L-phenylalanine methyl ester

A method for the recovery of .alpha.-L-aspartyl-L-phenylalanine methyl ester, L-phenylalanine and L-aspartic acid from the mother liquor obtained by the solid-liquid separation of a suspension of .alpha.-L-aspartyl-L-phenylalanine methyl ester crystals is disclosed.

Method for recovery of .alpha.-L-aspartyl-L-phenylalanine methyl ester,

A method of preparing .varies.-L-aspartyl-L-phenylalanine methyl ester hydrochloride (.varies.-APM.HCL) from a reaction mixture of N-formyl-L-aspartic acid anhydride and L-phenylalanine methyl ester (PM), wherein .alpha.-APM.HCl is produced without isolating an intermediate by solid-liquid separation during the course of the reaction process.

Method of preparing .alpha.-l-aspartyl-l-phenylalanine methyl ester

In neutralizing an acid addition salt of .alpha.-APM in an aqueous medium, the .alpha.-APM concentration in the neutralized liquid is controlled to fall within the range of from 3 to 10 wt. % at the finish of neutralization. Then, the liquid is heated to 50.degree. to 80.degree. C. and neutralization is effected with stirring to the isoelectric point of .alpha.-APM; or after the neutralization, the neutralized liquid is heated. The neutralized liquid is thereafter cooled with or without stirring so that crystals of .alpha.-APM are precipitated.

Method of preparing .alpha.-L-aspartyl-L-phenylalanine methyl ester

An acid addition salt of .alpha.-APM is dissolved or suspended in an aqueous medium at 50.degree. C. or lower at a pH of 3 or less and a concentration of the salt of 3 wt.% or more (solution A). A liquid having a pH of 3 or more and containing or not containing .alpha.-APM is prepared (solution B) and gradually mixed with solution A with stirring. The temperature of the liquid mixture is kept to be 40.degree. C. or lower and the pH value of the mixture is kept at 3 or more, optionally adding a base thereto, whereby crystals of .alpha.-APM are precipitated out.

A method of crystallizing phenylalanine in the form of .alpha.-crystals at a temperature below .alpha..fwdarw..beta. transition temperature comprises:

Method of crystallizing phenylalanine

Improved methods for synthesizing glutamine-containing peptides, involving an active ester method between a protected, C-terminal activated amino acid or a protected, C-terminal activated peptide, and unprotected glutamine in the presence of a weak base, are disclosed.

Process for the production of glutamine derivatives

The present invention relates to novel azetidinone derivatives of the general formula: ##STR1## where n is 0 or 2,

Growing community of inventors

Kawasaki, Japan

Toshihisa Kato