Mitsui Chemicals, Inc.

Toshihiro Tateno

Hiroshi Shimizu

Hitoshi Takahashi

Tadashi Araki

Mitsufumi Wada

Takashi Morishige

Tomonori Hidesaki

Junko Tokuda

Nozomi Takebayashi

Yoshiko Matsumoto

Ryota Fujii

Anjali Madhavan

Takashi Hirasawa

Tomokazu Shirai

Koh Amano

Su Sun Chong

Chikara Furusawa

Ayako Endo

Dominik Lukas Jürgen-Lohmann

Keiichirou Kai

A mutant nitrile hydratase that is derived fromand has an &#x3b1; subunit and a &#x3b2; subunit, wherein a specific amino acid residue has been substituted for the amino acid residue in at least one position selected from the group consisting of the 40th and 43rd residues from the N terminal of the &#x3b1; subunit, and the 205th, 206th, and 215th residues from the N terminal of the &#x3b2; subunit.

Mutant nitrile hydratase, nucleic acid coding said mutant nitrile hydratase, expression vector and transformant including said nucleic acid, production method for said mutant nitrile hydratase, and production method for amide compound

An acetyl-CoA-producing microorganism, which is capable of efficiently synthesizing acetyl-CoA using carbon dioxide, and a substance production method using the same are provided. An acetyl-CoA-producing microorganism including an acetyl-CoA production cycle obtained by imparting at least one type of enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism.

Microorganism having carbon dioxide fixation pathway introduced thereinto

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Mobara, Japan

Toshihiro Tateno