Pola Chemical Industries, Inc.

Pola Chemical Industries Inc., Japan

Toshihiro Morimoto

Masato Inazu

Takeshi Yamamoto

Makoto Kimura

Takayuki Namiki

Kenichi Kishii

Masayuki Yanagi

Nobuyuki Kawakatsu

Yuji Yoshiko

Kazunori Harada

Yoshiyuki Miyata

Masaki Mitani

Kyoko Yamasaki

Michihiko Tsujitani

Yoshiaki Motoki

Mariko Onoda

Ichiro Matsuo

Yoshiharu Momota

Ryoko Yokota

Tetsuo Katoh

Dopamine re-uptake inhibitor

Diphenylpiperazine derivative and drug for circulatory organ containing

Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives are disclosed. The compounds are represented by the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 individually represent a hydrogen atom, a linear or branched alkyl group which may have a substituent, a cycloalkyl or phenyl group which may have a substituent, or a heterocyclic group which may have a substituent, and R.sub.3 is a hydrogen atom or a cyano group. The compounds have excellent circulatory disease curing activities as well as bronchodilation activities.

Pyrrolo(3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine

Growing community of inventors

Yokohama, Japan

Toshihiro Morimoto