Daiichi Sankyo Company, Limited

Toshihiro Kiho

Kazumasa Aoki

Satoshi Komoriya

Kazuki Yano

Katsuhiro Kawakami

Taisaku Tanaka

Kentoku Gotanda

Atsushi Tengeiji

Tatsuya Yano

It is an object of the present invention to provide a new compound capable of efficiently inducing differentiation from pluripotent stem cells into insulin-producing cells. The object of the present invention is achieved by a compound represented by formula (I): 

Dihydroindolizinone derivative

Compounds or pharmacologically acceptable salts thereof for promoting osteogenesis, improving bone metabolism, preventing or treating bone fracture, preventing or treating a disease associated with bone metabolism, or in the field of orthopedics for the promotion of healing of bone fracture, a bone defect, and bone diseases such as osteoarthritis as well as in the field of dentistry for the treatment of periodontal disease and the stabilization of artificial tooth root. The compounds are represented by formula (I) or a pharmacologically acceptable salt thereof: 

Chromone derivative having osteogenesis promoting effect

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Funabashi, Japan

Toshihiro Kiho