Japan Tobacco Inc.

Toshihiro Kiguchi

Takashi Nakagawa

Teruhiko Inoue

Taku Ikenogami

Masanori Shindo

Yuko Shinagawa

Naoki Ogawa

Yuki Soejima

Kenji Fukuda

A compound represented by the following formula (1), a pharmaceutically acceptable salt thereof or an optically active form thereof: wherein each symbol is as defined in the specification. A compound having a calcium-sensing receptor antagonistic action, a pharmaceutical composition comprising the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis are provided.

CaSR antagonist

The present invention provides a compound having a calcium-sensitive receptor antagonistic action, a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis. A compound represented by the following formula (1), a pharmaceutically acceptable salt thereof or an optically active form thereof: wherein each symbol is as defined in the description.

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Takatsuki, Japan

Toshihiro Kiguchi