Mitsubishi Gas Chemical Company, Inc.

Toshihiro Hashimoto

Makoto Takagawa

Kenichi Nakamura

Takashi Motoi

Takeshi Koshikawa

Cyanogen chloride and dimethylamine are reacted in a water/organic solvent system. The organic solvent is immiscible with water. After the completion of reaction, the water-immiscible organic solvent is distilled away from the reaction product solution to carry out the subsequent synthesis of 1,1,3,3-tetramethylguanidine in an aqueous system.

Process for producing dimethylcyanamide

Provided is a process for producing benzoyl chlorides which comprises reacting an aromatic aldehyde with chlorine in liquid phase in the presence of inert gas, whereby the generation of benzal chlorides by products whose separation is difficult can be suppressed.

Process for producing benzoyl chlorides

A process for the production of a pyridinecarboxylic acid by the air-oxidation of an alkylpyridine in a liquid phase, in which the conversion of the alkylpyridine is high, the yield of the pyridinecarboxylic acid is therefore high, the content of impurities in the product is decreased, and unreacted raw material and an oxidation intermediate can be recycled without the adverse effect of accumulation of the catalyst and bromine component, the process comprising oxidizing an alkylpyridine with an oxygen-containing gas in a solvent in the presence of a catalyst formed of a heavy metal salt and a bromine compound, the solvent being a lower aliphatic monocarboxylic acid having a water content of 2 to 15% by weight, or the process comprising the step of catalytically hydrogenating an oxidation reaction mixture or an isolated pyridinecarboxylic acid in the presence of a catalyst of a metal belonging to the group VIII of the periodic table.

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Tsukuba, Japan

Toshihiro Hashimoto