Kowa Company Limited

Toshihiro Akashi

Masami Shiratsuchi

Kiyoshi Kawamura

Yasumi Uchida

Masahiko Nagakura

Hisashi Kunieda

Seiichi Sato

Yoshinori Kyotani

Hiromichi Shigyo

Noboru Shimizu

Naotoshi Sawada

Hiroshi Ishihama

Naoki Machida

A novel racemate K-351A composed of an optical isomer (2'S),(3S)K-351 [3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy-3-nitroxy-2H-1-benzop yran] and (2'R),(3R)K-351, a novel racemate K-351B composed of an optical isomer (2'R),(3S)K-351 and (2'S),(3R)K351 and an acid addition salt of these two novel racemates; a process for converting the two racemates to each other; and also to a pharmaceutical composition comprising each of the two racemates useful for the treatment of cardiovascular diseases.

Racemates of

An optical isomer selected from the group consisting of (2'R),(3R)-3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy-3-nitroxy-2 H-1-benzopyran, (2'S),(3R)-3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy-3-nitroxy-2 H-1-benzopyran and acid addition salts of these isomers, process for producing these isomers and a pharmaceutical composition thereof useful for the treatment of cardiovascular diseases.

Optical isomers, processes for production thereof and pharmaceutical

A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --O--CH.sub.2 --,

Aromatic aminoethanol compounds, and utilization thereof as

A benzopyran compound represented by the following ##STR1## wherein A represents a direct bond or the bond --CH.sub.2 --O--,

Dihydrobenzopyran compounds and pharmaceutical composition comprising

A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --0--CH.sub.2--,

Certain phenyl or pyridyl-propanol-amines containing alkyl-nitrate

Methylmethioninesulfonium compounds of the formula ##STR1## wherein X.crclbar. represents an anion;

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Higashimurayama, Japan

Toshihiro Akashi