Boston Biomedical, Inc.

Sumitomo Dainippon Pharma Co., Ltd.

Toshihiko Sone

Chiang Jia Li

Naoaki Shimada

Wei Li

Wataru Hirose

David Leggett

Yosuke Takanashi

Masanori Tobe

Katsumi Kubota

Tomoaki Nakamura

Tomoya Shiro

The present invention provides a compound of the following Formula (1) or a pharmaceutically acceptable salt thereof: wherein X is an oxygen atom and the like; Y is &#x2014;CO&#x2014;, &#x2014;SO&#x2014; and the like; Ris an optionally-substituted Calkyl group, an optionally-substituted Calkylcarbonyl group and the like; Ris an optionally-substituted Calkyl group, an optionally-substituted Calkoxy group, an optionally-substituted amino group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic saturated heterocyclic group and the like; R, R, R, and Rare independently a hydrogen atom and the like which exhibits excellent effects in suppressing the proliferation and sphere-forming ability of cancer cells, and can be useful as an antitumor drug or cell growth inhibitor.

3-substituted carbonyl-naphtho[2,3-B]furane derivative or pharmaceutically acceptable salt thereof

The present invention provides: an uracil derivative represented by general formula (I) or a physiologically acceptable salt thereof (in the formula, Rrepresents a hydrogen atom, a Calkyl group, a Calkene group or a 3- to 6-membered saturated or 4- to 6-membered unsaturated aliphatic ring group which may contain 1 to 2 hetero atoms independently selected from the group consisting of N, O and S; Rrepresents a hydrogen atom, a halogen atom, a cyano group, &#x2014;NRR, &#x2014;N&#x2550;CHN(CH), or an Calkyl group; Arand Arindependently represent a 5- to 6-membered aromatic ring group which may contain 1 to 3 hetero atoms independently selected from the group consisting of N, O and S; and L represents a 6-membered aromatic ring group which may contain 1 to 4 nitrogen atoms, a pyrazole group, a triazole group, or an imidazole group); and a therapeutic agent or prophylactic agent for various inflammatory diseases associated with elastase, comprises the compound or the like as an active ingredient. 

Uracil derivative and use thereof for medical purposes

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Osaka, Japan

Toshihiko Sone