Kanebo, Limited

Toshihiko Kohno

Goro Tsukamoto

Koichiro Yoshino

Takashi Nose

Keizo Ito

Masahiro Taguchi

Hajime Kagaya

Katsumi Dezawa

Tominori Morita

Keiso Ito

A phosphonic acid ester of the formula ##STR1## exhibits calcium-antagonistic, coronary vasodilating and hypotensive activities. Pharmaceutical compositions containing the same are useful for the prophylaxis and treatment of circulatory organ diseases such as angina pectoris, hypertension and the like.

Phosphonic acid ester, pharmaceutical compositions containing the same

2-Substituted benzimidazole compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, lower alkyl or lower alkoxy, and R.sub.2 is hydrogen or lower alkyl with the proviso that R.sub.1 and R.sub.2 do not stand for hydrogen simultaneously and, when R.sub.1 is hydrogen, R.sub.2 cannot mean a methyl group at 6th position on the pyridin-2-yl group or methyl an isobutyl group on the phenyl group; are useful as anti-inflammatory agents and/or analgesics.

2-Substituted benzimidazole compounds

2-Substituted benzimidazole compounds of the formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, lower alkyl or lower alkoxy, and R.sub.2 is hydrogen or lower alkyl with the proviso that R.sub.1 and R.sub.2 do not stand for hydrogen simultaneously and, when R.sub.1 is hydrogen, R.sub.2 cannot mean a methyl group at the 6th position on the pyridin-2-yl group or methyl an isobutyl group on the phenyl group; are useful as anti-inflammatory agents and/or analgesics.

Growing community of inventors

Sakai, Japan

Toshihiko Kohno