Sumitomo Electric Industries, Limited

Toshihiko Kishimoto

Takeshi Nakamura

Shinobu Tamaoki

Haruo Nakaji

Atsushi Uno

Shin-ichiro Niwa

Yumiko Oka

Tomoko Yamaguchi

Eiji Hara

Yasutaka Makino

Susumu Nakada

Taka-aki Tamura

Kinichiro Oda

The present invention relates to an optical amplifier with a structure for more effectively suppressing the over/undershoot in transient responses in high-speed AGC. This optical amplifier is an optical device for amplifying signal light inputted therein, and comprises a rare-earth-element-doped optical fiber, an optical coupler, a light-receiving section, a pumping light source, and a control section. In particular, as a typical structure of the optical amplifier, the rare-earth-element-doped optical fiber has a cutoff wavelength &#x3bb;c set longer than the pumping light wavelength &#x3bb;p but shorter than the signal light wavelength &#x3bb;s, and mainly allows a pumping light component in a fundamental mode to propagate therethrough. The pumping light and signal light are made incident on the first rare-earth-element-doped optical fiber such that only the pumping light component in the fundamental mode and a signal light component in the fundamental mode propagate through the first rare-earth-element-doped optical fiber in a state where the first rare-earth-element-doped optical fiber extends straight.

Optical amplifier

The present invention relates to a method of detecting an anti-GADII antibody, and a method of diagnosing cancer using this detecting method. In particular, it relates to a method of diagnosing cancer by detecting an anti-GADII antibody existing in serum. GADII protein increases upon the occurrence of hepatic cancer, and the antibody against GADII protein also increases upon the occurrence of hepatic cancer. As a result, the occurrence of cancer can be monitored by detecting the anti-GADII antibody.

Method for detecting anti-GADII antibody and method for diagnosing cancer using said detection method

Disclosed herein are Human Id genes (Id-1H and Id-1H') and variants thereof. Origin, preparation process, biochemical functions and the like: two synthetic oligonucleotides separately having base sequences corresponding to regions of amino acid sequence, which are almost completely conserved by three mouse Id genes (Id-1, Id-2 and HLH462) are used as probes to screen clones having respective cDNAs complementary to the probes from a cDNA library of human TIG-1 fibroblasts in accordance with the hybridization method, thereby isolating human Id genes. The expression of the human Id genes specifically varies according to the state of cell proliferation, in particular, the acquisition of cell aging and permanently proliferating ability. Expression vectors with the human Id gene or variant thereof integrated therein, transformed cell strains with the expression vector introduced therein, diagnostic probes obtained by chemically synthesizing a partial sequence of the base sequence of the human Id gene, or a variation sequence thereof, and antisense oligonucleotides composed of a base sequences complementary to the partial sequence of the base sequence of the human Id gene, or the variation sequence thereof are also disclosed.

Human ID genes

A method of extracting a particular nucleic acid fragment containing a nucleic acid sequence of interest from a nucleic acid or nucleic acids mixture, comprising the steps of:

Method of extracting particular nucleic acid fragment

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Yokohama, Japan

Toshihiko Kishimoto