Sankyo Company, Limited

Toppan Printing Co., Ltd.

Toshihiko Hashimoto

Yukio Sugimura

Kimio Iino

Tomoyuki Shibata

Teruo Tanaka

Shinichi Sugawara

Tetsuo Miyadera

Tomowo Kobayashi

Shigeki Muramatsu

Yukiko Kameyama

Hiroyuki Koike

Masayuki Iwata

Toshio Sada

Masaki Nojima

Toshiji Fujita

Kazuo Yarita

Hidekazu Masuko

Compounds of formula (I): ##STR1## in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): ##STR2## (in which R.sup.1, R.sup.2 and R.sup.7 are various organic groups, n is 0, 1 or 2 and X is a direct carbon-carbon bond or lower alkylene) show valuable anti-tumor activity and may be prepared by reacting an amine-platinum complex with a compound providing the group represented by Z.

Anti-tumor platinum complexes, their preparation and their therapeutic

Compounds of the formula: ##STR1## in which: R.sup.1 is a trifluoromethyl or a pentafluoroethyl;

Benzopyran derivatives having anti-hypertensive and vasodilatory

Compounds of formula (I): ##STR1## wherein: one or both of R.sup.1 and R.sup.2 are selected from a variety of organic groups;

2-(1-aceti

Compounds of formula (I): ##STR1## (wherein R.sup.1 is carboxy, --CONR.sup.4 R.sup.5, cyano or hydroxymethyl, and R.sup.2 and R.sup.3 are hydrogen, alkyl or substituted alkyl, R.sup.4 and R.sup.5 being hydrogen or a variety of groups) have good antibiotic activity and reduced renal toxicity.

Carbapenem compounds and use

A method and apparatus for obtaining an accurate half-tone dot percent of each color separation where a color designated by a color specimen is to be reproduced by printing of ink of the colors, for example, yellow, magenta, cyan and black. A variety of color charts printed using predetermined combinations of half-tone dot percents are optically measured to obtain color information of the colors printed on the color charts. The obtained color information values together with the corresponding predetermined combinations of half-tone dot percents therefor are then utilized to prepare a conversion table of color information and corresponding half-tone dot percents for reproducing each of the colors printed on the color charts. A color specimen is then optically measured to detect color information of a color to be reproduced. The color information obtained from the color specimen is then successively compared with the color information of the conversion table, and the color information of the conversion table is selected which most closely corresponds to the color information obtained from the color specimen. The combination of half-tone dot percents corresponding to the selected color information from the conversion table is then displayed or otherwise outputted. The outputted combination of half-tone dot percents may then be used to reproduce the color designated by the color specimen. The method and apparatus also provides for interpolation operations if the color information obtained from the specimen does not precisely correspond to the color information in the conversion table. Further, the method and apparatus also provides for generating an expanded conversion table having expanded combinations of half-tone dot percents and corresponding expanded color information, and for performing an interpolation operation if a value of 0% and/or 100% is included in the combination of half-tone dot percents corresponding to the selected color information so as to obtain an interpolated combination of half-tone dot percents corresponding more closely to the color information obtained from the color specimen.

Method and apparatus using a conversion table based on pre-printed color

Compounds of formula (I): ##STR1## in which: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;

2-penem-3-carboxylic acid derivatives and use

Compounds of formula (I): ##STR1## (wherein R.sup.1 represents a C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.3 alpha-hydroxyalkyl group;

Penem derivatives, and composition containing them

Compounds of formula (I): ##STR1## [wherein: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;

Growing community of inventors

Tokyo, Japan

Toshihiko Hashimoto