Msd K.k.

Banyu Pharmaceutical Co. Ltd

Toshihide Nishibata

Yasuhiro Goto

Toshihiro Sakamoto

Kenji Niiyama

Keiji Takahashi

Hidetomo Furuyama

Makoto Bamba

Takeshi Sagara

Fuyuki Yamamoto

Hiroshi Hirai

Takashi Yoshizumi

Satoshi Sunami

Sachie Otsuki

The invention relates to compounds of a general formula (I): wherein Aris an optionally-substituted aryl or heteroaromatic group; Ris an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; Ris a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; Ris a hydrogen atom or a lower alkyl group; Ris a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of &#x2014;N(R)R; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.

Dihydropyrazolopyrimidinone derivatives

Substituted pyrazolo[3,4-d]pyrimidinone derivatives

Growing community of inventors

Tsukuba, Japan

Toshihide Nishibata