Ueno Fine Chemicals Industry, Ltd.

Toshihide Komatsu

Yusuke Kita

Takaya Hisano

Mio Tsuchiya

Munehiro Nishimura

Kuniyo Yanagawase

Hiroki Tsunematsu

The present invention relates to a production process of a 4-hydroxy-benzoic acid long chain ester, that includes a step of reacting a 4-hydroxy-benzoic acid short chain ester with an aliphatic alcohol in the presence of a metal catalyst. The present invention also relates to a purification process of a 4-hydroxy-benzoic acid long chain ester, that includes a step of adding an acid aqueous solution to a crude composition including the 4-hydroxy-benzoic acid long chain ester, separating the crude composition to an organic phase and a water phase and extracting the organic phase.

Production process and purification process of 4-hydroxy-benzoic acid long chain ester

The present invention provides a liquid antiseptic composition including (A) parahydroxybenzoic acid ester and (B) water-miscible organic solvent, wherein the (A) parahydroxybenzoic acid ester are two or more esters selected from the group consisting of methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, isobutyl parahydroxybenzoate and benzyl parahydroxybenzoate; the (B) water-miscible organic solvent contains (B-1) at least one organic solvent selected from the group consisting of propylene glycol, butylene glycol, ethanol and polyethylene glycol, and (B-2) 2-phenoxyethanol; and a weight ratio of (A) and (B) is 1:1 to 1:3, and a weight ratio of (B-1) and (B-2) is 1:1 to 1:3.

Liquid antiseptic composition and method for producing the same

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Kobe, Japan

Toshihide Komatsu