Gunze Limited

Toshiharu Shinoka

Yoshito Ikada

Shuhei Tara

Hidetaka Nakayama

Yuki Sakamoto

Shojiro Matsuda

Tsuguyoshi Taira

Goki Matsumura

Kosuke Sawai

Hirotsugu Kurobe

Tadahisa Sugiura

The present invention aims to provide a method for producing a porous substrate containing a bioabsorbable polymer and heparin in a simple manner without use of a surfactant, a porous substrate containing a bioabsorbable polymer and heparin, and an artificial blood vessel. The present invention provides a method for producing a porous substrate containing a bioabsorbable polymer and heparin, including: a solution preparing step of preparing a heparin-bioabsorbable polymer solution having heparin uniformly dispersed therein and a bioabsorbable polymer dissolved therein, using the bioabsorbable polymer, the heparin, a solvent 1 that is a poor solvent having a lower solvency for the bioabsorbable polymer, a solvent 2 that is a good solvent having a higher solvency for the bioabsorbable polymer and is incompatible with the solvent 1, and a common solvent 3 compatible with the solvent 1 and the solvent 2; a precipitating step of cooling the heparin-bioabsorbable polymer solution to precipitate a porous body containing the bioabsorbable polymer and the heparin; and a freeze-drying step of freeze-drying the porous body containing the bioabsorbable polymer and the heparin to provide a porous substrate containing the heparin.

Method for producing porous substrate comprising bioabsorbable polymer that contains heparin, porous substrate comprising bioabsorbable polymer that contains heparin, and artificial blood vessel

The present invention aims to provide a method for producing a porous tissue regeneration substrate that allows a wide choice of solvents and easy adjustment of the bulk density and pore size of the porous substrate. The present invention also aims to provide a method for producing an artificial blood vessel and an artificial blood vessel. The present invention relates a porous, tubular artificial blood vessel containing a bioabsorbable material, the artificial blood vessel including: a skin layer having a relatively small pore size as an innermost layer; and a porous layer positioned around the skin layer and having a relatively large pore size.

Artificial blood vessel, method for producing artificial blood vessel, and method for producing porous tissue regeneration substrate

The scaffold for culturing a cardiovascular tissue of the present invention is a scaffold for culturing a cardiovascular tissue, which is tubular, and comprises a foamed polymer comprising a bioabsorbable material reinforced with a reinforcing material comprising a bioabsorbable material, the foamed polymer comprising lactide (D, L, DL isomer)-&#x3b5;-caprolactone copolymer containing lactide (D, L, DL isomer) in a content of 50 to 54 mole % and &#x3b5;-caprolactone in a content of 50 to 46 mole %, and the reinforcing material being covered with the foamed polymer.

Substrate for culture of cardiovascular tissue

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Tokyo, Japan

Toshiharu Shinoka