Toyo Jozo Kabushiki Kaisha

Toyo Jozo Company, Ltd.

Toshiharu Noda

Kaoru Morita

Shigeo Katsuragi

Susumu Watanabe

Nobuaki Nakagawa

Masayuki Hori

Kunio Ohyama

Sadami Kobari

Toyonobu Uzawa

Eisuke Munekata

Tadanori Morikawa

Tadashiro Fujii

Masaru Otani

Kunio Matsumoto

Tetsuo Matsuda

Kikuo Kotani

Masahiko Taniuchi

Tosio Meguro

Yasuo Nakagawa

Shunpei Sakakibara

Kazuhiko Matsumoto

Shuichi Kitazawa

Nobutaka Fujii

Shumpei Sakakibara

Hirose Yamauchi

Terutoshi Kimura

A compound of the formula ##STR1## wherein Y is sulfur or methylene and A is Asn or Asp, or a pharmaceutically acceptable salt thereof is useful for the treatment of calcium metabolic disorders, cardiac disease and ulcers, and for the improvement of cranial circulation.

Calcitonin gene related peptide derivatives

A compound of the formula ##STR1## wherein R is H or H-Ala-NH- and when A is Asp, B is Asp or Glu, C is Leu and D is Val; when A is Asn and B is Gly, C is Phe and D is Gly; when A is Asn, B is Asp or Glu and C is Leu, D is Gly; and when A is Asn, B is Asp or Glu, and C is Phe, D is Val, or a pharmaceutically acceptable salt thereof, is useful for the treatment of calcium metabolic disorders, cardiac disease and ulcers, and for the improvement of cerebral circulation.

Calcitonin-gene-related peptide derivatives

A peptide represented by the following formula: ##STR1## wherein Y means a sulfur atom or methylene group, A stands for Asp or Asn, B denotes Val or Met and C is Asn or Ser, or a salt thereof.

A peptide of the formula ##STR1## wherein A is Tyr or Phe, or a pharmaceutically acceptable salt thereof, is useful for the diagnosis of parathyroid gland function. When A is Tyr, the peptide can be labelled with iodine-125 without losing its PTH activity and without undergoing oxidation upon storage.

[Nle.sup.8, Nle.sup.18, Tyr.sup.34 or Phe.sup.34 ]-h-PTH peptide

Process for the preparation of antibodies

Peptides for assaying human parathyroid hormone

C-Terminal fragment of human chorionic gonadotropin

Novel amine compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl and R.sub.2 is substituted methyl amino or D-amino acid residue, or a salt thereof. R.sub.1 can typically be isobutyl or methyl; and R.sub.2 can be methylamino of the formula

Assay method of enzyme activity

Polypeptides of the formula ##STR1## wherein A.sub.1 is Ser or Gly, A.sub.7 is Val or Met, A.sub.10 is Lys or Thr, A.sub.11 is Leu or Tyr, A.sub.12 is Ser or Thr, A.sub.14 is Glu or Asp, A.sub.15 is Leu or Phe, A.sub.16 is His or Asn, A.sub.18 is Leu or Phe, A.sub.19 is Gln or His, A.sub.21 is Tyr or Phe, A.sub.23 is Arg or Gln, A.sub.25 is Asp or Asn or Ala, A.sub.26 is Val or Thr or Ile, A.sub.28 is Ala or Ser or Val, and A.sub.30 is Thr or Val or Ala, and pharmaceutically acceptable acid addition salts and complexes, have serum calcium reducing activity.

Polypeptides and process for producing the same

A polypeptide having calcitonin activity of the formula ##EQU1## and the salts thereof with pharmaceutically acceptable acids.

EEL calcitonin

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Shizuoka, Japan

Toshiharu Noda