Teijin Limited

Teijin Pharma Limited

Toshie Fujishima

Hiroaki Takayama

Hiroshi Saito

Kazuya Takenouchi

Seiichi Ishizuka

Nozomi Saito

Katsuhiro Konno

Kazuhisa Okada

Daishiro Miura

Atsushi Kittaka

Miyuki Anzai

A compound represented by the following Formula (1) that is effective for the treatment of Paget's disease of bone or hypercalcemia or a medically acceptable solvate thereof; [wherein Rrefers to hydrogen atom, C-Calkyl group optionally substituted with hydrogen group or C-Calkoxy group optionally substituted with hydroxyl group, Rand Rrefer to hydrogen atom, C-Calkyl group optionally substituted with hydroxyl group, C-Caryl group optionally substituted with hydroxyl group or C-Caralkyl group optionally substituted with a hydroxyl group, or are combined to represent ethylene group. However, a compound in which Ris a hydrogen atom or a methyl group and Rand Rare hydrogen atoms is excluded].

[object Object]

Provided are 1,25-dihydroxy-2-methylvitamin D3 derivatives expressed by the general formula (I),[wherein each of Rand Ris independently a hydrogen atom or a tri(Cto Calkyl)silyl group; herein configurations of asymmetric carbons at the 1-, 2- and 3-positions are each independently &#x3b1;-configuration or &#x3b2;-configuration] and their production methods. The compound is useful as a treating agent for osteoporosis, rickets, hyperthyroidism, etc.

Vitamin D3 derivative and its production method

Growing community of inventors

Kanagawa, Japan

Toshie Fujishima