Ajinomoto Co., Ltd.

Toshiaki Tsuji

Masao Nakamura

Shinichi Kishimoto

Toshihide Yukawa

Haruo Kawasaki

Takashi Yamashita

N-formyl-.alpha.-L-aspartyl-L-phenylalanine methyl ester is obtained by reacting L-phenylalanine methyl ester with N-formyl-L-aspartic acid anhydride in a reaction solvent containing acetic acid or acetic acid and formic acid in a complete mixing type continuous reaction mode.

Process for the production of N-formyl-alpha-L-aspartyl-L-phenylalanine

A process for producing N-formyl-aspartylphenylalanine or its methyl ester, wherein aspartic acid is reacted with formic acid and acetic anhydride in approximately stoichiometric quantities in the presence or absence of a catalyst and phenylalanine or its methyl ester is directly added to the dehydration mixture. This process has a higher yield of the desired N-formyl-dipeptide and minimizes the amount of by-products and unreacted starting materials.

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Yokkaichi, Japan

Toshiaki Tsuji