Okinawa Research Center Co., Ltd.

Other

University of the Ryukyus

Erina Co., Inc.

University of the Ryunkyus

Akihisa, Toshihiro

Nagai, Kazuo

Toshiaki Teruya

Je-Tae Woo

Kazuo Nagai

Byung-Yoon Cha

Yuto Teruya

Takayuki Yonezawa

Toshihiro Akihisa

Masato Ohta

Miki Yamada

Takayuki Yonezama

Kozue Sasaki

Aki Yamano

Hiroyuki Akazawa

Midori Asai

Saki Sugiyama

Kosuke Sueyoshi

Ayaka Hibino

The object is to provide a method of manufacturing a fraction containing nobiletin and tangeretin at high concentrations, which is excellent in terms of safety, economic efficiency, and the potential for industrialization. The method includes (1-1) a step of treating citrus fruit with hot water to obtain a hot water-treated product; (1-2) a step of drying the hot water-treated product to obtain a dried product; (1-3) a step of treating the dried product with a solvent capable of dissolving nobiletin and tangeretin to obtain a nobiletin and tangeretin solution; (3) a step of concentrating and/or drying the nobiletin and tangeretin solution to obtain a nobiletin and tangeretin concentrate; and (4) a step of treating the nobiletin and tangeretin concentrate with a dilute alkali to obtain a composition containing nobiletin and tangeretin as an insoluble component, and by a composition containing nobiletin and tangeretin at high concentrations manufactured by the method.

Method for manufacturing composition containing nobiletin and tangeretin derived from citrus fruits, and composition containing nobiletin and tangeretin obtained thereby

An objective of the present invention is to provide a method for producing a nepodin-containing extract containing a high concentration of nepodin with less contaminants present therein thereby being able to be readily carried out on an industrial scale, when compared to the conventional techniques. The objective is solved by A method for producing a nepodin-containingplant extract, the method comprising the following steps (1) to (5): (1) a step of subjecting aplant to an extraction treatment using a nepodin-dissolving solvent to obtain a crudeplant extract; (2) a step of subjecting the crudeplant extract to a water-adding treatment and/or concentration treatment to obtain a solid crudeplant extract; (3) a step of subjecting the solid crudeplant extract to a weak alkali treatment to obtain a weak alkali insoluble product; (4) a step of subjecting the weak alkali insoluble product to a strong alkali treatment to obtain a strong alkali soluble product; and (5) a step of subjecting the strong alkali soluble product to a neutralization treatment to obtain the nepodin-containingplant extract.

Method of producing high-nepodin-containing rumex plant extract and high-nepodin-containing rumex plant extract

The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising thereof, a functional food comprising thereof. Since the present invention comprises the arylheptanoid compound shown in the following formula (I) and the derivatives thereof, it enables to prevent and/or treat the bone disease. (In the formula (I), Rand Rare a functional group selected from the group consisting of a hydrogen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R, R, and Rare a functional group selected from the group consisting of a hydrogen atom, an oxygen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; Rmay be bound on meta-position against heptylene group of another aryl group to form a ring.)

Pharmaceutical composition for preventing and/or treating bone disease, functional food or health food and pharmaceutical preparation comprising thereof as active ingredient

Agents or pharmaceutical compositions for promoting osteoblast differentiation include purified auraptene or coumarin analogs thereof represented by the following formula 1: wherein R1 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, or a carboxyethyl; R2 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, a carboxyethyl or a coumarinyl; R3 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl or a carboxyethyl; and R4 represents a hydrogen, a C-Cliner or branched alkyl, an alkenyl, an alkadienyl or an alkatrienyl.

Agent for promoting osteoblast differentiation, pharmaceutical composition for promoting bone formation, and food for special dietary use containing auraptene analog as active ingredient

Growing community of inventors

Nakagami-gun, Japan

Toshiaki Teruya