Fujita Academy

Toshiaki Shibata

Naohiro Kanayama

Kazuhiro Sugihara

Yuichiro Onodera

Michiko N Fukuda

Motohiro Nonaka

Michiko Fukuda

The present invention is a cytocidal agent including a peptide consisting of an amino acid sequence represented by SEQ ID NO: 1 and a site selectively binding to a target molecule, in which the peptide consisting of an amino acid sequence represented by SEQ ID NO: 1 is a peptide exclusively consisting of L-amino acids, a peptide in which, in amino acid sequences represented by SEQ ID NO: 1, the first to the 14amino acids are D-amino acids, and the 15to 19amino acids are L-amino acids, a peptide in which, in amino acid sequences represented by SEQ ID NO: 1, the first to 14amino acids are L-amino acids, and the 15to the 19amino acids are D-amino acids, or a peptide exclusively consisting of D-amino acids.

Cytocidal agent

An object of the present invention is to provide a peptide drug that is able to selectively induce apoptosis in target cells. The present invention is a cytocidal agent containing a fusion peptide of an endosome escape peptide and an apoptosis-inducing peptide, which consists of an amino acid sequence represented by SEQ ID NO: 1, and the said cytocidal agent as a therapeutic agent for a disease caused by abnormal proliferation of cells.

Growing community of inventors

Hamamatsu, Japan

Toshiaki Shibata