Kaken Pharmaceutical Company, Ltd.

Toray Industries, Inc.

Toshiaki Okuda

Tsutomu Nakamura

Motoyuki Yajima

Makoto Okumura

Jun Nakano

Yoshiyuki Hiyama

Kiyoshi Kuriyama

Toshikazu Awaji

The present invention relates to a preparation, particularly a topical preparation, for the therapy of wounds or hemorrhoids, which contains, as an active ingredient, at least one of prostaglandin I.sub.2, prostaglandin E.sub.1 and derivatives of these, particularly beraprost, a derivative of prostaglandin I.sub.2, or a salt thereof, and a method of the therapy of wounds or hemorrhoids, which comprises administering the above active ingredient.

Preparation for treating wounds or hemorrhoids

A chromene derivative having the general formula (I): ##STR1## wherein n is 1 to 5 and --O--CH.sub.2).sub.n CO.sub.2 H group is attached to 5-position, 6-position, 7-position or 8-position, or salts thereof, a process for preparing the same and antiallergic agents containing the same. The compounds of the present invention inhibit the immunological release of chemical mediators such as SRS-A and histamine from mast cell and have an excellent effect in preventing and treating the various allergic diseases such as allergic asthma, allergic dermatitis, allergic nasitis, hives, allergic enteritis and allergic conjunctivitis, especially allergic asthma.

Coumarin derivatives and antiallergic agents containing the same

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Kyoto, Japan

Toshiaki Okuda