Sankyo Company, Limited

Toshiaki Matsuzawa

Noritoshi Kitano

Yasuhiro Morisawa

Mitsuru Kataoka

Akio Torikata

Mamoru Arai

Hisayoshi Fukatsu

Pyridine derivatives having the formula ##STR1## wherein R.sub.1 is an alkyl group having 1 to 3 carbon atoms; R.sub.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R.sub.3 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 or 4 carbon atoms, an alkyl group having 1 or 2 carbon atoms and hydroxy as a substituent, an alkanoyl group having 1 to 18 carbon atoms, an alkenoyl group having 3 to 11 carbon atoms, an aromatic acyl group having 6 or 10 carbon atoms in the aromatic ring and optionally alkyl, alkoxy, acetylamino, cyano or halogen as a substituent, a heterocyclic acyl group, an alkylcarbamoyl group having 1 to 4 carbon atoms in the alkyl moiety, an allylcarbamoyl group or hydroxy group; n is an integer of 0 to 2 inclusive; and, when n is 2, R.sub.1 's may be the same or different; provided that when R.sub.2 is said alkyl group having 1 to 3 carbon atoms, R.sub.3 is said alkyl group having 1 to 4 carbon atoms. They are highly effective in the treatment of coccidiosis.

Pyridine derivatives and their use as anticoccidial agents

Anticoccidial compositions which comprise as active ingredient pyridine derivatives having the formula ##STR1## wherein R.sub.1 is hydrogen atom, a halomethyl group or methyl group;

Compositions and methods for the treatment of coccidiosis

An anticoccidial composition which comprises a compound of the formula ##SPC1## Intimately dispersed in an inert edible carrier, wherein R.sub.1 and R.sub.2 are each hydrogen, an aliphatic acyl group, an aromatic acyl group or a heterocyclic acyl group, and at least R.sub.1 and R.sub.2 is said heterocyclic acyl group; or a salt thereof. The composition is a preventive and curative anticoccidial agent for poultry and domestic animals. Particularly, it shows a significant activity against chronic coccidiosis caused by Eimeria acervulina. The composition is less toxic for animals, besides it has an advantage that it is also effective for coccidiosis caused by coccidia resistant to the known anticoccidial agents.

Substituted pyridinol-containing compositions and methods for the

Antibiotic substance named 'Pholipomycin' which is useful as a growth promoting agent for domestic animals, poultries and the like and produced by the cultivation of a new microorganism, Streptomyces lividoclavatus strain No. 3176, NRRL 8022.

New antibiotic substance, its preparation and its use as growth

A composition which comprises a pyridinol derivative of the formula ##SPC1## Intimately dispersed in an inert edible carrier, wherein R.sub.1 and R.sub.2 may be the same or different and each represents a hydrogen atom; a lower alkyl group, an aralkyl group, an aliphatic, an aromatic or a heterocyclic acyl group; an alkoxycarbonyl group; an aralkoxycarbonyl group; an aryloxycarbonyl group; a N-substituted carbonyl group; a N-substituted thiocarbonyl group; a phosphono group; or a salt thereof. The composition is a preventive and curative anticoccidial agent for poultry and domestic animals. Particularly, it shows a significant activity against chronic coccidiosis caused by Eimeria acervulina. The composition is less toxic for animals, besides it has an advantage that it is also effective for coccidiosis caused by coccidia resistant to the known anticoccidial agents.

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Tokyo, Japan

Toshiaki Matsuzawa