Dainippon Pharmaceutical Company, Limited

Asahi Glass Company, Limited

Toshiaki Kadokawa

Hitoshi Uno

Katsuyoshi Kawashima

Katsuhiko Hino

Yasushi Matsumura

Arata Yasuda

Keiichi Uchida

Yoshinobu Masuda

Haruki Nishimura

Mikio Kurokawa

Yoshiaki Ochi

Shunsuke Naruto

Junji Nakano

Buichi Fujitani

Naonobu Hatano

Tomoyuki Asai

Hiroyuki Mizuta

Kayoko Zushi

Agent for treating ischemic brain damage

A 6-fluoroprostaglandin having the formula: ##STR1## wherein A is a carbonyl group or a hydroxymethylene group, R.sup.1 is a substituted or unsubstituted C.sub.1 -C.sub.10 alkyl group or a substituted or unsubstituted 5- or 6-membered cycloalkyl group, R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.10 alkyl group, each of R.sup.3 and R.sup.4 which may be the same or different is a hydrogen atom or a protecting group, R.sup.5 is a hydrogen atom or a hydroxyl group, and is a single bond or a double bond, and its salt when R.sup.2 is a hydrogen atom.

6-fluoroprostaglandins

2-(1-piperazinyl)-4-substituted phenylquinoline derivatives, processes

Use of a compound of the formula: ##STR1## wherein R is hydrogen atom or ethyl group, or a pharmaceutically acceptable salt thereof for prophylaxis and/or treatment of peptic ulcer, and a method for prophylaxis and/or treatment of peptic ulcer disease which comprises administering an effective amount of the above-mentioned compound to warm blooded aninal, especially human. Said active compounds have excellent pharmacological activities such as inhibition of ulceration and inhibition of gastric secretion, and hence, are useful as an anti-peptic ulcer agent.

Anti-peptic ulcer agent

Novel 2-cyclic amino-2-(1,2-benzisoxazol-3-yl)acetic acid derivatives of the formula: ##STR1## wherein R.sub.1 is hydrogen or a halogen atom, R.sub.2 is a lower alkyl group, Am is a 5- to 9-membered saturated cyclic amino group which may be substituted by a lower alkyl group, and the group: ##STR2## binds to the piperidine moiety at 3- or 4-position of the latter, and their pharmaceutically acceptable acid addition salts and quaternary ammonium salts, process for their preparation, and pharmaceutical compositions containing these compounds. They have potent anticholinergic antispasmodic activity, while they are weak in side effects such as mydriasis, inhibition of salivary secretion and tachycardia.

2-Cyclic amino-2-(1,2-benzisoxazol-3-yl)acetic acid ester derivatives,

1,3-Disubstituted thiourea compounds represented by the following formula: ##EQU1## and their pharmaceutically acceptable acid addition salts which are useful especially for prevention and treatment of hypoxemia and further various diseases caused by hypoxia in local tissues, and process for the preparation of the present compounds set forth above and pharmaceutical composition containing the present compounds as an essential active ingredient.

1,3-Disubstituted thiourea compounds and preparation thereof

Growing community of inventors

Hirakata, Japan

Toshiaki Kadokawa