Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

Toshi Kunikata

Masashi Kurimoto

Haruki Okamura

Kakuji Torigoe

Keizo Kohno

Tadao Tanimoto

Mutsuko Taniguchi

A protein which induces the IFN-&#x3b3; production by immunocompetent cells and has a molecular weight of 19,000&#xb1;5,000 daltons on SDS-PAGE or gel filtration method and a pI of 4.8&#xb1;1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it. The monoclonal antibody can be also used for assaying the protein.

IFN-&#x3b3; production inducing protein (IGIF, IL-18)

A protein which induces IFN-.gamma. production by immunocompetent cells and has a molecular weight of 19,000.+-.5,000 daltons on SDS-PAGE or gel filtration and a pI of 4.8.+-.1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it. The monoclonal antibody can be also used for assaying the protein.

Interferon-gamma (IFN-.gamma.) inducing factor (IGIF, IL-18) purified

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Okayama, Japan

Toshi Kunikata