Aventis Pharmaceuticals Inc.

Aventis Pharmaceuticals Products Inc.

Tory H Powner

Michael K O'Brien

Patrick Leon

Ching T Tsuei

Matthew R Powers

Luc Grondard

Adam W Sledeski

Benoit J Vanasse

Laurence W Reilly

Gregory G Kubiak

Herve Garcia

Sithamalli V Chandramouli

Laurence Pailleres-Hubert

Benoit Viguier

Francis L Walther

Michael D Thompson

Harshavadan C Shah

Methods for stereoselective substitution in which a (mono or un)-&agr;-substituted unprotected &bgr;-amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium compounds, lithium hydride, lithium amide, lithium dialkyl amides and alkali hexamethyldisilylamines.

Alpha-substitution of unprotected &bgr;-amino ester compounds

This invention is directed to a process for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.

Process for preparing N6-substituted adenosine derivatives

This invention is directed to methods for the preparation of [1S-[1a,2b,3b,4a(S*)]]-4-[7-[[1-(3-chloro-2-thienyl) methyl]propyl]amino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxyc yclopentanecarboxamide, methods for the preparation of intermediates thereto, and to said intermediates themselves.

Preparation of

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Chester, VA, United States of America

Tory H Powner