Chugai Seiyaku Kabushiki Kaisha

Saitama Medical University

Yamatake Corporation

Utsunomiya University

Lexi Co., Ltd.

Arthrodesign, Ltd.

Toru Yoshizawa

Hitoshi Sasaki

Daisuke Kameoka

Megumi Numata

So Yamaguchi

Hiroko Murata

Naoka Hironiwa

Yukitoshi Otani

Toshitaka Wakayama

Hisatoshi Fujiwara

Yukari Kito

Norio Seitoku

Takashi Handa

In one non-limiting embodiment, the present disclosure relates to lyophilized formulations containing an IL-31 antagonist (for example, an anti-IL-31RA antibody) as an active ingredient, the lyophilized formulations further containing arginine and/or a salt thereof and sucrose and/or trehalose. In another non-limiting embodiment, the present disclosure relates to solution formulations containing an IL-31 antagonist as an active ingredient, the solution formulations further containing arginine and/or a salt thereof. In other non-limiting embodiments, the present disclosure relates to methods for stabilizing an antibody (for example, an anti-IL-31RA antibody) in an antibody-containing formulation, methods for suppressing antibody aggregation (aggregate formation) in an antibody-containing formulation, and methods for reducing components with charge heterogeneity in an antibody-containing formulation, the methods being characterized in that the formulation is prepared to contain arginine and/or a salt thereof, and/or sucrose and/or trehalose.

Anti-IL-31RA antibody-containing formulations

Methods of administering anti-IL31A antibody-containing formulations

Anti-IL31RA antibody-containing formulations

CT images near the pelvis are obtained before surgery, and a three-dimensional model of a pelvis part is created on a computer. The virtual three-dimensional bone model is used to plan an installation position of a guide instrument etc., and a virtual three-dimensional surgical site model including the guide instrument is constructed. Subsequently, during surgery, the guide instrument is installed, and three-dimensional images of a surgical site are obtained, and a measured three-dimensional surgical site model including the guide instrument is obtained. The virtual three-dimensional surgical site model and the measured three-dimensional surgical site model are compared, and an error between an ideal installation position of the guide instrument and an actual installation position of the guide instrument is detected to guide the operator to reduce the error.

Navigation device for joint replacement and surgical support device

An axially symmetric polarization conversion element that converts incident light into an axially symmetric polarized beam includes a reflection section having a shape obtained by rotating the cross section of a Fresnel rhomb wave plate along the direction of an optical axis around an axis that is parallel to the optical axis. The axially symmetric polarization conversion element converts the incident light into an axially symmetric polarized beam by utilizing two Fresnel reflections by the reflection section.

Axially symmetric polarization conversion element

A grating () is disposed to face the measurement target surface of a measurement target object (). A light source () irradiates the grating () with illumination light. A camera () captures a moire fringe image formed on the grating () by light passing through the gratingand reflected by the measurement target surface. A moving means () changes the distance (H) between the gratingand the measurement target surface. An analyzing means () performs an analysis process of obtaining 3-D shape information of the measurement target surface from the image picked up by the camera () in at least two cases in which the distance (H) is set to different values, and obtains, on the basis of the 3-D shape information in each case and the distance H, true 3-D shape information from which the measurement error caused by the inclination of the measurement target surface is eliminated.

Surface shape measuring system

Growing community of inventors

Tokyo, Japan

Toru Yoshizawa