University of Tsukuba

Toru Yoshitomi

Yukio Nagasaki

Aki Hirayama

Atsushi Ueda

Yutaka Ikeda

Akira Matsumura

Aiki Marushima

Mayo Yamashita

Daisuke Miyamoto

Md Amran Hossain

Min Ley Pua

Tomoki Yoshinari

Hideo Tsurushima

Tatsuya Yaguchi

Kazuko Toh

Shiro Ishii

Pennapa Chonpathompikunlert

Hirofumi Matsui

Junya Kaneko

Takashi Mamiya

Kensuke Suzuki

[Problem] To provide a physiologically active peptide-loaded stable composition for injection into living bodies. [Solution] A composition containing a triblock copolymer represented by formula (I), a polyanionic polymer and a physiologically active peptide:CNR-PEG-CNR&#x2003;&#x2003;(I)

Composition containing polycationic triblock copolymer, polyanionic polymer and physiologically active peptide

Provided is a triblock copolymer represented by General Formula (I):CNR-PEG-CNR&#x2003;&#x2003;(1)or a polycation thereof, wherein

Triblock copolymer and use therefor

Provided is an organic-inorganic hybrid composite of a polymerized cyclic nitroxide radical compound and inorganic nanoparticles. Such a composite is capable, for example, of maintaining a stable nanoparticle shape in gastric fluid, and can be used by itself or as a carrier for delivery of another drug to the intestines.

Organic-inorganic hybrid composite of polymerized nitroxide compound and inorganic particles

A method of covalently bonding a cyclic nitroxide radical compound to a hydrophobic block of a specific hydrophylic-phobic block copolymer, and polymerized cyclic nitroxide radical compound copolymerized in this manner, as well as use of such a compound, for instance, in the medical field are provided. The compound demonstrates long term stability in vivo under reductive environment.

Polymerized cyclic nitroxide radical compound and use thereof

Growing community of inventors

Ibaraki, Japan

Toru Yoshitomi