Yamanouchi Pharmaceutical Company Ltd.

Toru Yoden

Masafumi Kudou

Yasuo Isomura

Minoru Okada

Eiji Kawaminami

Isao Yanagisawa

Yuzo Matsumoto

Wataru Uchida

Ryuji Tsuzuki

Akira Matsuhisa

Seijiro Akamatsu

Akira Suga

Yoshiaki Shimada

Tsukasa Ishihara

Noriaki Nagano

Tetsuya Maeda

Masaki Yokota

Masaharu Asano

Ryuichiro Hara

Tokuo Koide

Kazuhisa Takayama

Hideki Anan

Ei-ichi Nakai

Katsuhiko Hamaguchi

Masato Sato

Azole derivative and pharmaceutical composition thereof

Triazolylated teritiary amine compound or salt thereof

Substituted tertiary amino compound or salt thereof

##STR1## A compound represented by general formula (I), a pharmaceutical composition containing same, a process for the production thereof, and an intermediate therefor. In formula (I) R.sup.1 represents lower alkyl which may be substituted by a substituent selected from the group consisting of mercapto, lower alkylthio, arylthio and lower acylthio; R.sup.2, R.sup.3 and R.sup.4 may be the same or different from one another and each represents lower alkyl; X represents oxygen or sulfur; and Y represents a single bond or lower alkylene. The compound (I) has a matrix metalloprotease inhibitory activity and is useful for preventing and treating diseases caused by the progress of connective tissue breakage.

Hydroxamic acid derivative

Novel benzoxazine derivatives of the formula (I): ##STR1## are provided as well as their pharmaceutically acceptable salts and a method for their use as potassium channel activating agents 2-(3,4-Dihydro-2, 2-dimethyl-6-phenylsulfonyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide is illustrative of a benzoxazine derivative of formula (I). Also provided are intermediate compounds such as those of formula (II): ##STR2##

3,4-dihydro-2H-1,4-benzoxazine derivatives and pharmaceutical

Oxazinobenzazole derivatives represented by the formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each independently represents a hydrogen atom or a lower alkyl group; R.sup.5 and R.sup.6 jointly form, in conjunction with the two adjacent carbon atoms, a substituted or unsubstituted 5- or 6-membered heterocyclic ring having at least two nitrogen atoms and optionally having one or more heteroatom(s) selected from the group consisting of an oxygen atom, a sulphur atom and a nitrogen atom; and m is an integer of 0 or 1, and pharmaceutically acceptable salts thereof. The compounds of the present invention are useful as antispasmodic medicaments.

Oxazinobenzazole compounds

A cephalosporin compound represented by the general formula: ##STR1## This compound exhibits a high antimicrobial activity.

Cephalosporin derivatives

Growing community of inventors

Ibaraki, Japan

Toru Yoden