Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Isao Kawamoto

Toru Yasuzawa

Isami Takahashi

Eiji Kobayashi

Hirofumi Nakano

Keiichi Takahashi

Hiroshi Sano

Hiroshi Kase

Katsuhiko Ando

Koji Yamada

Satoshi Nakanishi

Joji Goto

Noriaki Hirayama

Etsuyo Shimizu

Makoto Morimoto

Tadashi Ashizawa

Katsuichi Shuto

Fusao Tomita

Michio Ichimura

Kazutoshi Kuroda

Yoshinori Yamashita

Masaji Kasai

Chikara Murakata

Kunikatsu Shirahata

Hiromitsu Saito

Shunji Ichikawa

Mitsunobu Hara

Kozo Asano

Shigeo Katsumata

Tatsuhiro Ogawa

Kazuhisa Fujimoto

Yuzuru Matauda

Kozo Asasno

Kenichi Muroi

KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.

KS-506 compounds

2,4-dihydroxy-3,5,6-trimethylbenzoic acid compounds

Novel DC-89 compounds represented by the general formula: ##STR1## wherein X represents a single bond or --CH.sub.2 --; and when X represents a single bond, Y represents --CH.sub.2 Br or --CH.sub.2 Cl and when X represents --CH.sub.2 --, Y represents Br, are obtained by the present invention. The compounds have antibacterial and anti-tumor activity.

DC-89 compounds and process for their preparation

A novel fermentation product, DC113, represented by the formula ##STR1## which has antimicrobial and antitumor activities.

Novel substance DC 113 and production thereof

Disclosed are KS-501 derivatives represented by the formula (I) ##STR1## wherein X represents a hydrogen atom or COOR.sub.3, Y represents hydroxy or ##STR2## and R.sub.1, R.sub.2 and R.sub.3 are the same or different and represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, provided that when R.sub.1, R.sub.2 and R.sub.3 are simultaneously hydrogen atoms, and when R.sub.1, R.sub.2 and X are simultaneously hydrogen atoms, Y does not represent ##STR3## and a pharmaceutically acceptable acid addition salt thereof. The KS-501 derivatives have a platelet aggregation-inhibiting property, and are expected to be useful as antithrombotic agent.

KS-501 derivatives

Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.

Novel substances KS-504a, KS-504b, KS-504d and KS-504e and process for

Novel physiologically active substances Ks-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.

A novel physiologically active substance KS-619-1 having a vasodilative activity is produced by culturing Streptomyces californicus ATCC 3312.

Novel substance KS-619-1, preparation process and pharmaceutical

Compounds having analgesic activity which have the formula ##STR1## wherein R.sub.1 -R.sub.6 represent hydrogen or a substituent and X and Y together represent inter alia as epoxyethylene, ethylene halohydrin, haloethylene or a --CH.dbd.CH-group.

UCY1003 derivatives

The present invention relates to DC-88A and DC-89A1 and their production. These compounds are obtained by fermentation of microorganisms belonging to the genus Streptomyces. These compounds have antibacterial and anti-tumor activities and are useful as medicaments.

Pyrindamycins A and B and duocarmycin A antibiotics derived from certain

Novel substance UCY1003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities: ##STR1##

Novel substance UCY1003 and process for preparing the same

Novel physiologically active substances KS-501 and KS-502 having inhibitory activity on serotonin release from platelets and/or platelet aggregation are produced by culturing a microorganism of the genus Sporothrix.

Novel substances KS-501 and KS-502 and process for their preparation

Antibiotic compounds DC-92B and DC-92D

Growing community of inventors

Machida, Japan

Toru Yasuzawa