Nippon Chemiphar Co., Ltd.

Toru Yamanaka

Yasuo Fujimoto

Shigeru Yamabe

Yoshihiro Tanaka

Kiyosato Nyu

Shoji Ryu

Yoshio Suzuki

Mitsuo Masaki

Kazuki Okai

Mitsuko Yoshioka

Taketoshi Kinoshita

An N-acylcarnosine aluminum salt of the formula, ##STR1## wherein R represents a lower alkyl group having 1 to 6 carbon atoms is effective for use as an anti-ulcer agent.

N-Acrylcarnosine aluminum salts

An N-acylcarnosine aluminum salt of the formula, ##STR1## Wherein R represents a lower alkyl group or a phenyl group, and n is an integer of 2 to 3 is effective for use as a digestive ulcer-remedying or anti-ulcer agent.

N-Acylcarnosine aluminum salts

9-(.beta.-hydroxyethyl) piperazinyl-carbonyl-2-trifluoromethyl-10, 11-dihydrodibenzo[b,f]thiepin is prepared and disclosed as having antiinflamatory action.

Benzo[b,f]thiepan derivitives

Novel benzo [b,f] thiepin derivatives possessing strong anti-flammatory action and presenting few adverse reactions, of the formula (I) ##STR1## wherein R represents a fluorine atom, or a trifluoromethyl or 1-5C lower alkoxy group, and R.sub.3 and R.sub.4 each represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 together with the adjacent nitrogen atom to which they are attached form a heterocyclic group. Pharmaceutical compositions comprising an anti-inflammatory effective amount of the compound according to formula (I) in the presence of an inert carrier.

Benzo[b,f]thiepin derivatives and process for producing the same

Dihydrodibenzo[b,f]thiepin compounds of formula (I) and process for making them. These compounds have antiinflammatory action. ##STR1## wherein R represents a hydrogen, fluorine atom, a trifluoromethyl, 1-5C lower alkoxy, hydroxy, hydroxyethoxy, aminoethoxy group or the group of the formula --OCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OH, Y represents a hydroxy group or the group of the formula ##STR2## (R.sub.3 and R.sub.4 represent a 1-4C lower alkyl group or R.sub.3 and R.sub.4 may jointly form a heterocyclic group together with an adjacent nitrogen atom.

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Misato, Japan

Toru Yamanaka