Nissan Chemical Industries Limited

Toru Tsukagoshi

Kazufumi Yanagihara

Kazuhiko Ohrai

Toru Yamashita

Yukihiro Shigeta

Keizo Tanikawa

Yoshio Ohara

Tomoyuki Matsuda

Takayuki Nagatsuka

Norio Hashimoto

This invention relates to benzopyran compounds of formula (I) wherein X is NR, Y is a bond, SO or SO, Z is Calkyl group or phenyl group, W is hydrogen atom, hydroxy group, Calkoxy group, a halogen atom, Calkyl group or Calkylsulfonylamino group, Rand Rare independently of each other Calkyl group, Ris hydrogen atom, hydroxy group or methoxy group, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CRR, NR, O, S, SO or SO, Ris hydrogen atom or Calkyl group, Ris hydrogen atom, Calkyl group, Ccycloalkyl group, Ccycloalkenyl group, Caryl group or Cheteroaryl group. These compounds are useful as an anti-arrhythmic agent.

Benzopyran compound

This invention relates to benzopyran derivatives of the formula (1) or the formula (2) wherein Rand Rrepresent independently of each other hydrogen atom or Calkyl group, Rrepresents hydroxyl group or Calkylcarbonyloxy group, Rrepresents hydrogen atom or Calkyl group, Rrepresents Calkyl group substituted with Caryl group or heteroaryl group, Rrepresents Calkyl group, Calkoxy group, halogen atom, nitro group, C(O)NH, C(O)NHRor C(O)NRR, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent 

Substituted benzopyran derivatives against arrhythmia

This invention relates to benzopyran derivatives of the formula (I) wherein, R and R represent each independently a C alkyl group, etc, R represents a hydroxyl group, etc, R represents a hydrogen atom, etc, R represents a hydrogen atom, R represents a hydrogen atom, etc, X is absent, or represents C&boxH;O, etc, R represents a hydrogen atom, a C alkyl group, etc, R represents a hydrogen atom or a nitro group, when R represents a nitro group, Y represents a C alkylene group, &mdash;(CH ) &mdash;CR R &mdash;(CH ) &mdash; or &mdash;(CH ) &mdash;O&mdash;(CH ) &mdash;, R represents a hydrogen atom, an amino group, a C alkoxy group, a C alkylthio group, a C alkylamino group, a C alkoxycarbonylamino group, etc, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent.

4-aminobenzopyran derivatives

This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R and R represent each independently a hydrogen atom, a C alkyl group or a phenyl group; R represents a hydroxyl group or C alkylcarbonyloxy group; R represents a hydrogen atom, a C cycloalkyl group, a C alkyl group, a C alkylcarbonyl group, a C alkylaminocarbonyl group, a di-C alkylaminocarbonyl group, an aryl group or a heteroaryl group; R represents a hydrogen atom or a C alkyl group; X is absent or represents C&boxH;O or SO ; R represents a hydrogen atom, a C alkyl group or a C cycloalkyl group; R represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. And this invention also relates to a drug for treating arrhytmia having the prolongation effect on the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.

4-oxybenzopyran derivative

Benzopyran derivative

This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R and R represent each independently a hydrogen atom, a C alkyl group or a phenyl group; R represents a hydroxyl group or a C alkylcarbonyloxy group; R represents a hydrogen atom, a C cycloalkyl group, a C alkyl group, a C alkylcarbonyl group, a C alkylaminocarbonyl group, a di-C alkylaminocarbonyl group, an aryl group or a heteroaryl group; n represents an integer of 0-4; X represents &mdash;C(&boxH;O)NR &mdash;, &mdash;NR &mdash;, &mdash;NHC(&boxH;O)NH&mdash; or &mdash;S(O) NH&mdash;; R5 represents a hydrogen atom or (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), or (l); R represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. And this invention also relates to an antiarrhythmic agent having the prolongation effect of the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.

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Funabashi, Japan

Toru Tsukagoshi