Toray Industries, Inc.

Kawasumi Laboratories. Inc.

Shiga University of Medical Science

Toru Tani

Kazuo Teramoto

Masashi Kodama

Shiro Nishiumi

Totaro Oka

Kazuyoshi Hanazawa

Mutsuo Murakami

Tomokazu Mukai

By Yoshimasa Katayama, Heir

Sumihiro Kamitani

By Shigemasa Katayama, Heir

Yutaka Katayama, Deceased

By Nobuko Katayama, Heir

An object of the present invention is to provide an anti-adhesion material having sufficient in vivo degradability and excellent anti-adhesion characteristics, and also superior to conventional ones in terms of handling properties under wet conditions. The anti-adhesion material () of the present invention has a sheet-like base layer () containing a water soluble polymer (e.g., pullulan), a first cover layer () placed on a surface on one side of the base layer () and containing an aliphatic ester, and a second cover layer () placed on a surface on the other side of the base layer () and containing an aliphatic ester. The optical thickness of each of the first cover layer () and the second cover layer () is set to be 27 nm or greater and smaller than 160 nm.

Anti-adhesion material

Lipopolysaccharides derived from the cell walls of Gram-negative bacteria, also known as endotoxins or pyrogens, are immobilized on a solid, insoluble carrier. The blood, blood plasma or blood serum of a tumor-bearing patient is passed over the immobilized lipopolysaccharide-containing blood treating material to treat the patient's tumor.

Method of treating malignant tumors

The present invention provides (1) an endotoxin detoxifying material comprising a fibrous carrier to which Polymyxin is fixed, (2) an endotoxin detoxifying material comprising a carrier to which Polymyxin and a basic nitrogen atom are fixed, and (3) a method of removing endotoxin from a fluid by contacting the fluid with the endotoxin detoxifying material comprising a carrier to which Polymyxin is fixed. The present invention makes it possible to contact blood with Polymixin directly and safely and gives a new method of therapy endotoxemia or prophylaxis of endotoxemia.

Endotoxin detoxifying material

The present invention provides (1) an endotoxin detoxifying material comprising a fibrous carrier to which Polymyxin is fixed, (2) an endotoxin detoxifying material comprising a carrier to which Polymyxin and a basic nitrogen atom are fixed, and (3) a method of removing endotoxin from a fluid by contacting the fluid with the endotoxin detoxifying material comprising a carrier to which Polymyxin is fixed. The present invention makes it possible to contact blood with Polymixin directly and safely and gives a new method of therapy of endotoxemia or prophylaxis of endotoxemia.

Endotoxin detoxifying process

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Shiga, Japan

Toru Tani