Otsuka Pharmaceutical Company, Limited

Otsuka Techno Corporation

Otsuko Techno Corporation

Toru Nishibayashi

Tetsuya Sato

Shintaro Adachi

Takaaki Nakao

Yoshihiro Ishizue

Kozo Ishida

Kai Suzuki

Akitsuna Akagi

Masaaki Odomi

Atsuya Nakamura

Yusuke Ogawa

Masanori Kubo

Kaszuyo Koshino

Mattias Lindström

Patrik Palovaara

Mikael Lindberg

This invention provides a suspension for oral administration comprising particles containing amorphous tolvaptan that can inhibit or delay crystallization of amorphous tolvaptan over time in the suspension, and stably maintain high solubility of tolvaptan and excellent absorbability of tolvaptan from the gastrointestinal tract; and a solid formulation for oral administration that can be suspended to prepare the suspension for oral administration at the time of use. This invention relates to a suspension for oral administration, in particular, a syrup, comprising (a) particles containing amorphous tolvaptan, (b) hydroxypropyl methylcellulose (HPMC), and (c) a solvent, wherein the amount of the HPMC (b) is 0.1 to 25% by weight based on the total weight of the suspension for oral administration.

Suspension for oral administration comprising amorphous tolvaptan

A powder inhaler includes: a housing having a port; a storage member located in the housing for storing a powder medicament; and a medicament-delivery member provided in the housing. The medicament-delivery member includes at least one concave portion for receiving medicament, and is capable of taking, relative to the storage member, a receiving position wherein the concave portion receives a predetermined amount of powder medicament from the storage member, and an inhalation position wherein the powder medicament can be inhaled through the admission port; and a stirring member for stirring the powder medicament stored in the storage member. An operation button is provided in the housing and is capable of moving between the initial position and a depressed position, while the operation button reciprocates between the initial position and the depressed position, the concave portion in the medicament-delivery member moves from the receiving position to the inhalation position and the stirring member operates.

Powder inhaler

The subject invention provides a powder inhaler enabling the user to complete powder drug inhalation with fewer steps, for improved user convenience. A powder inhaler of the present invention comprises:

A powder inhalator including: a housing, a supply member for holding a powdered drug for a large number of doses and having a drug discharge aperture at its bottom surface; a drug carrier, to which the powdered drug is supplied from the drug discharge aperture of the supply member, and having on its upper surface a measuring recess that has a volume equivalent to one dose of the drug; and an operation member disposed so as to move freely back and forth, and operate the drug carrier; the drug carrier moving in contact with the bottom surface of the supply member to carry the powdered drug loaded into the measuring recess from the position of the drug discharge aperture to an air inhalation channel, wherein the drug carrier is disposed slidably so that the measuring recess moves in a circular manner by sliding the drug carrier.

Powder inhalator

Inhaler

A powder inhalator comprising: a housing; a supply member for holding a powdered drug for a large number of doses and having a drug discharge aperture at its bottom surface; a drug carrier, to which the powdered drug is supplied from the drug discharge aperture of the supply member, and having on its upper surface a measuring recess that has a volume equivalent to one dose of the drug; and an operation member disposed so as to move freely back and forth, and operate the drug carrier; the drug carrier moving in contact with the bottom surface of the supply member to carry the powdered drug loaded into the measuring recess from the position of the drug discharge aperture to an air inhalation channel, wherein the drug carrier is disposed slidably so that the measuring recess moves in a circular manner by sliding the drug carrier.

A highly absorbable pharmaceutical composition containing, as the active ingredient, methyl 3-phenyl-2(E)-propenyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate in an amorphous state and a pH-dependent type copolymer of methacrylic acid or its derivatives which composition has been prepared by dissolving the two components together in an organic solvent and thereafter removing the solvent.

Highly absorbable pharmaceutical composition

Particulate preparation containing a flourracil derivative and

Growing community of inventors

Tokushima, Japan

Toru Nishibayashi