Takara Shuzo Co., Inc.

Nippon Kayaku Kabushiki Kaisha

Takara Bio Inc.

Toru Kurome

Ikunoshin Kato

Kazutoh Takesako

Naoyuki Awazu

Kaoru Inami

Tetsuo Shiba

Tetsushi Saino

Yoshihisa Umeda

Makoto Moriguchi

Keiko Miyazaki

Tetsuya Inoue

A novel cyclic peptide having an antifungal activity, its pharmacologically acceptable salts and antifungal medicinal compositions containing the same.

Cyclic peptide

Sphingosine derivatives and medicinal composition

Sphingosine analogues

Aureobasidins

To provide a process for the total synthesis of a cyclic peptide, which is useful as antifungal drug, and novel compounds prepared by the synthesis method. A process for synthesizing a cyclic peptide represented by the following formula (I): ##STR1## wherein X1, X2, X4 and X7 are independently N-methyl-.alpha.-amino acid or .alpha.-hydroxy acid,

Cyclic peptides

A process is provided for the total synthesis of a cyclic peptide, which is useful as antifungal drug, and novel compounds prepared by the synthesis method. The cyclic peptide is represented by the following formula (I): ##STR1## wherein X1, X2, X4 and X7 are independently N-methyl-.alpha.-amino acid or .alpha.-hydroxy acid,

Process for systhesizing cyclic peptides

Process for purifying spergualin-related compounds and their synthetic intermediates, by subjecting a solution containing such spergualin-related compounds or intermediates to electrodialysis and/or reverse osmosis.

Process for the purification of spergualin-related compounds

Growing community of inventors

Otsu, Japan

Toru Kurome