Asahi Kasei Kogyo Kabushiki Kaisha

Toru Kuroda

Nobuaki Tsuda

Yoshinori Takenaka

Naokuni Yamawaki

Naoya Kominami

Kenji Inagaki

Norio Iriguchi

An adsorbent for adsorbing thereonto an autoantibody and/or immune complexes from a body fluid. The adsorbent comprises a surface, a hydrophobic member and a negative charge-producing member. The negative charge-producing member is adapted to produce such an effective number of negative charges in a body fluid that the ratio of: ##EQU1## is greater than 1. The adsorbent is excellent in selectively and efficiently adsorbing an autoantibody and/or immune complexes while little adsorbing useful substances from the body fluid. The adsorbent may be used in an adsorbing device comprising a vessel having a fluid inlet and a fluid outlet with the adsorbent contained in the vessel. The adsorbing device may be used in a blood purifying apparatus for adsorbing and removing an autoantibody and/or immune complexes from blood plasma, which apparatus comprises a blood circulation passage provided with a plasma separating means and a blood-plasma mixing means, and a plasma recycle passage connected to the blood circulation passage and adapted to introduce plasma, separated by the plasma separating means and purified by a plasma purifying means comprised of the above-mentioned adsorbing device and disposed in the plasma recycle passage, into the mixing device.

Absorbent of autoantibody and immune complexes, adsorbing device and

An adsorbent for adsorbing low density lipoproteins, which comprises a surface and, linked with the surface, at least one member selected from a silanol group and a synthetic polyanion member having a molecular weight of 600 or more, and has pores of diameters widely distributed in a specific range. The adsorbent has a high adsorbing capacity for low density lipoproteins and is useful for purifying and regenerating a body fluid with high selectivity for low density lipoproteins.

Porous adsorbent for adsorbing low density lipoproteins

Leukocytes are separated from a leukocyte-containing suspension by bringing the leukocyte-containing suspension into contact with a leukocyte-separating material, whereby a substantial part of the leukocytes are entrapped in the leukocyte-separating material, and then, collecting the entrapped leukocytes. The leukocyte-separating material used comprises a fibrous material having a surface layer composed of a substance which is capable of being dissolved in water by degrees. Lymphocytes can also be separated in a manner similar to that mentioned above, from a lymphocyte-containing suspension having reduced contents of granulocytes and monocytes.

Separation of leukocytes or lymphocytes from leukocyte-containing

Leukocytes are advantageously separated from blood or other leukocyte-containing suspensions by causing the leukocyte-containing suspensions to flow through a filter unit comprising a container provided with inlet and outlet conduit means and with a mass of fibers packed therein. The mass of fibers is characterized as possessing a bulk density of from 0.02 to 0.40 gram/cubic centimeter, and each of the fibers is characterized as having an average diameter of from 3 to 10 microns. The fibers to be used are selected from synthetic fibers, semi-synthetic fibers, regenerated fibers and natural proteinaceous fibers.

Separation of leukocytes from leukocyte-containing suspension by

Lymphocytes are advantageously separated from blood or other lymphocyte-containing suspensions by a method wherein the lymphocyte-containing suspension is flowed through a second filter having a mass of fibers exhibiting an average fiber diameter of greater than 10 microns but not greater than 60 microns, thereby to entrap a substantial part of granulocytes and monocytes in the mass of fibers and to obtain a granulocyte-poor and monocyte-poor lymphocyte-containing suspension; and then, the obtained suspension is flowed through a first filter having a mass of fibers exhibiting a bulk density of 0.04 to 0.40 g/cm.sup.3 and an average fiber diameter of 5 to 20 microns, said average fiber diameter being less than that of the second filter, thereby to entrap a substantial part of lymphocytes in the mass of fibers; and finally, the lymphocytes entrapped in the mass of fibers of the first filter is collected. Alternatively, another method is employed wherein the lymphocyte-containing suspension is flowed through the first filter thereby to entrap a substantial part of leukocyte components therein; and the leukocyte components entrapped in the first filter is collected to obtain a leukocyte component-rich suspension; and finally, the leukocyte component-rich suspension is flowed through the second filter thereby to entrap a substantial part of granulocytes and monocytes in the second filter and to obtain a lymphocyte-rich suspension.

Separation of lymphocytes from lymphocyte-containing suspension by

A two step type pressurized injector comprising as main parts, a medicine chamber for holding an injecting liquid, a piston for pressurizing the injecting liquid, a nozzle hole for ejecting the injecting liquid, a power means for displacing said piston and a regulating means for regulating the displacement of said piston is provided. This injector gives less irritation i.e. pain to the skin of a person who is receiving the injection and less external injury to the skin. The injection is carried out under a pressure of 120 Kg/cm.sup.2 or higher to effect rapid perforation to a skin and then under a pressure of 100 Kg/cm.sup.2 or lower after the perforation.

Growing community of inventors

Fuji, Japan

Toru Kuroda