Shionogi Company Limited

Mochida Pharmaceutical Co., Ltd.

Toru Kita

Yuichi Ishikawa

Yasushi Saito

Masayuki Narisada

Yuji Matsuzawa

Masunori Matsuzaki

Masami Doteuchi

Mitsuhiro Yokoyama

Hideki Origasa

Shuh Narumiya

Hiroshige Itakura

Shinichi Oikawa

Kunio Shirato

Kazuyuki Shimada

Toshiie Sakata

Noriaki Nakaya

Akira Kitabatake

Hitoshi Hishida

Jun Sasaki

Hiroshi Harada

Fumihiko Watanabe

Toshiro Konoike

Saichi Matsumoto

Takuji Mizui

Eiichi Ohsugi

Fumrhio Watanabe

Provided are composition and/or methods useful in preventing onset and/or recurrence of cardiovascular events, especially in patients who have escaped the unstable period after cardiovascular angioplasty or in hyperlipidemia patients who have been treated with HMG-CoA RI.

Composition and/or method for preventing onset and/or recurrence of cardiovascular events

A 2,4,6-substituted phenol having the formula (I): ##STR1## wherein X is S or CH.sub.2 ; R.sup.1 and R.sup.2 are the same or different from each other and each is a lower alkyl group; R.sup.3 is a group of the formula: ##STR2## in which R.sup.4 is hydrogen atom or a lower alkyl group; R.sup.5 and R.sup.6 are the same or different from each other and each is hydrogen atom, a lower alkyl group, or a phenyl group which may be substituted, or a pharmaceutically acceptable salt thereof is useful as an active agent in a pharmaceutical composition. The pharmaceutical composition comprises a therapeutically effective amount of a compound having the formula (I), as an effective ingredient, in association with a pharmaceutically acceptable substantially nontoxic carrier or excipient. The pharmaceutical composition can be useful in the treatment of lipemia of mammals. Additionally the compounds can be used as antiatherosclerotic agents and antilipenic agents.

2,4,6-substituted phenol derivatives

Phenolic thioethers of the formula: ##STR1## wherein R is a hydrogen atom or a protective group for carboxyl, X is a straight or branched C.sub.4 -C.sub.15 alkylene group, a straight or branched C.sub.1 -C.sub.15 alkylene group having a phenylene group or a straight or branched C.sub.2 -C.sub.15 alkenylene group, and their salts, which inhibit the denaturation of low density lipoproteins (LDL) and the incorporation of LDL by macrophages and are useful as anti-arteriosclerosis agents.

Phenolic thioethers, and their production and use

(Di-tert-butylhydroxyphenyl)thio derivatives of the formula: ##STR1## wherein R is cyano, carbamoyl, or 5-tetrazolyl; n is an integer of 2 to 6; provided that when R is cyano, n is not 2; or a pharmaceutically acceptable salt thereof; useful in treating arterioschlerosis, ulcer, inflammation, allergy, or the like.

(Di-tert-butylhydroxyphenyl)thio derivatives and antiarterioschlerosis

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Kyoto, Japan

Toru Kita