The Green Cross Corporation

Nissan Chemical Industries Limited

Toru Iwao

Kazumasa Yokoyama

Koichi Yamanouchi

Nobuo Kondoh

Kenichi Hirai

Yasuo Ueda

Nobuo Kondo

Tomoyo Seki

A composition for oral administration which contains a pyridazinone compound of the formula (I) ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each independently a hydrogen atom or a lower alkyl, X is a halogen atom, a cyano or a hydrogen atom, Y is a halogen atom, a trifluoromethyl or a hydrogen atom, and A is a C.sub.1 -C.sub.8 alkylene optionally substituted by hydroxy, or a pharmacologically acceptable salt thereof, and an organic acid. According to the present invention, a composition for oral administration which is stable to heat, light, moisture and the like and which shows improved dissolution and absorption of a pyridazinone compound can be provided.

Composition for oral administration containing pyridazinone compounds

The orally administrable pharmaceutical compositions containing a slightly water-soluble drug, characterized by improved stability and improved absorption of the drug from digestive tract into blood. The use of the compositions of the present invention enables decrease of the dose amount of a slightly water-soluble drug, which eventually leads to alleviation of pains and side effects on the part of patients.

Pharmaceutical Composition containing slightly water-soluble drug

Pharmaceutical composition containing slightly water-soluble drug

Growing community of inventors

Hirakata, Japan

Toru Iwao