Nisshin Flour Milling Co., Ltd.

Toru Hayakawa

Haruhiko Kikuchi

Hiroaki Satoh

Setsuko Mino

Koichiro Hagihara

Makoto Yanai

Nobuhiro Yahata

Masashi Suzuki

Takeo Arai

Kazuhiko Yamada

Ruta Fukutomi

Toshio Suguro

Kiochiro Hagihara

Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalkyl, aryl, heteroarylalkyl or arylalkyl, the aryl group and the aryl moiety being optionally substituted by alkoxy, nitro, alkyl, amino or halo;

Diazabicyclo derivatives

Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;

Azabicyclo derivatives

Disclosed are compounds of formula (I) ##STR1## in which A is ##STR2## The compounds are selective antagonists of 5HT at 5-HT.sub.3 receptors and useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.

Piperidine derivatives

Azabicyclo derivatives and their use as antiemetics

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Kawagoe, Japan

Toru Hayakawa