Takeda Chemical Industries, Inc.

Toru Hasegawa

Seiichi Tanida

Mitsuko Asai

Eiji Higashide

Masayuki Muroi

Motowo Izawa

Kazunori Hatano

Masahiko Yoneda

Setsuo Harada

Satoshi Horii

Ikuo Nogami

Hiroshi Fukase

Yukimasa Nozaki

Akira Imada

Toshiyuki Yamazaki

Hidesuke Iwasaki

Hygromycin, epihygromycin and a mixture thereof have potent inhibitory activity against Treponema hyodysenteriae and are useful for treatment of swine dysentery.

Method for treatment of swine dysentery

A compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents hydrogen or methyl and X is ##STR2## provided that when R.sub.1 is hydrogen, R.sub.2 is hydrogen or methyl and X is ##STR3## and when R.sub.1 is methyl, R.sub.2 is methyl and X is ##STR4## is produced by cultivating a a microorganism belonging to the genus Streptomyces in a culture medium. Said compound is useful as an antimicrobial agent and so forth.

Antibiotic TAN-420

Macbecin derivatives are produced by cultivating a microorganism of the genus Actinosynnema in a culture medium. The Macbecin derivatives are useful as antibacterial, antifungal or antiprotozoal agent.

Macbecin derivatives and their production

Novel antibiotic C-15003 PHM, which is produced by cultivating a microorganism belonging to the genus Nocardia and being capable of producing antibiotic C-15003 PHM, and novel C-15003 PHM acylate, which is produced by subjecting C-15003 PHM thus obtained to acylation reaction with an acylating agent, have antiprotozoan and antitumor activities.

Antibiotic C-15003 PHM and production thereof

Macbecin derivatives

Maytansinoids

The present invention relates to a substantially pure culture of the microorganism belonging to the genus Nocardia, which microorganism is capable of producing in a culture medium containing assimilable carbon and digestible nitrogen sources, a recoverable amount of the Antibiotic C-14919 E-1 or E-2 or mixtures thereof having the characteristics described in the specification. These antibiotics have a wide range of antibiotic activity and they are useful as germicides or disinfectants.

Biologically pure culture of the microorganism Nocardia ATCC31280

The present invention relates to a method of producing the antibiotics C-14919 E-1 and/or E-2 by cultivating an antibiotic C-14919 E-1 and/or E-2 producing strain of the genus Nocardia in a culture medium and accumulating said antibiotics. These antibiotics have a wide range of antibiotic activity and they are useful as germicides or disinfectants.

Antibiotics produced from the microorganism nocardia

A novel Antibiotic C-11924 F-1 is produced by cultivating a microorganism belonging to the genus Streptoverticillium and capable of producing Antibiotic C-11924 F-1 in a culture medium, causing the microorganism to accumulate Antibiotic C-11924 F-1 in the cultured broth and recovering the same therefrom. Antibiotic C-11924 F-1 is useful for a germicide or disinfectant.

Antibiotic C-11924 F-1

The present invention relates to antibiotics C-14919 E-1 and E-2 produced by cultivating a microorganism of the genus Nocardia. These antibiotics display a wide activity against e.g. Gram-positive bacteria, fungi and yeast and are useful as germicides or disinfectants.

Antibiotics produced from the microorganism nocardice

This invention provides a method for producing Antibiotic T-42082 wherein the method comprises cultivating an Antibiotic T-42082-producing strain of the genus Streptomyces (ATCC 31080) to permit said strain to elaborate and accumulate Antibiotic T-42082 in the resultant broth and harvesting the antibiotic from said broth. This invention also includes the novel antibiotic.

Method for producing antibiotic T-42082 and antibiotic T-42082

A novel antibiotic C-2801-X represented by the formula ##STR1## is produced by cultivating a microorganism of the genus Streptomyces. The compound is useful in the treatment of mammals, including human beings, suffering from urinary tract infections, respiratory tract infections, colitis, septicema, purulent diseases, etc.

7-Methoxycephalosporin derivatives

A novel aminoglycoside antibiotic, xylostasin, of the nomenclature O-.beta.-D-xylofuranosyl-(1.fwdarw.5)-O-[.alpha.-2,6-diamino-2,6-dideoxy-D -glucopyranosyl-(1.fwdarw.4)]-2-deoxystreptamine and its pharmaceutically acceptable acid salts which are effective against infections with bacteria, and a process for producing the antibiotic by cultivating a strain belonging to the genus Bacillus which is capable of producing the antibiotic.

Growing community of inventors

Kawanishi, Japan

Toru Hasegawa