National Institute of Advanced Industrial Science and Technology

Hokusan Co. Ltd

Kitasato Daiichi Sankyo Vaccine Co., Ltd.

School Juridical Person the Kitasato Institute

Toru Gotanda

Akira Ito

Takeshi Matsumura

Noriko Itchoda

Noriko Tabayashi

Uiko Kagaya

Emiko Isogai

Kazuaki Takehara

Nobutoshi Maehara

Kuniaki Yoshioka

Ko Sato

Takashi Aoki

Shigeki Kobayashi

Katsumi Kume

Hanae Sasaki

Hiromi Ikadai

It is an object of the present invention to provide a transmission-blocking vaccine using an immunogenic protein which is specifically expressed in the oocyst stage of malaria parasites or a peptide fragment thereof, and an oral transmission-blocking vaccine capable of immunizing various animals involved in the malaria infectious cycle with such a vaccine. The present invention relates to a malaria transmission-blocking vaccine for oral administration containing an immunogenic protein derived from malaria parasite which is specifically expressed in the oocyst stage of malaria parasites or a peptide fragment thereof, and a method of blocking the transmission of malaria using the same.

Malaria transmission blocking vaccine

The object of the present invention is to provide a therapeutic agent illustrating an immediate and sustained effect on chronic intractable external otitis. The present invention provide a composition, pharmaceutical composition, food and feed for preventing and/or treating chronic intractable external otitis, each comprising interferon-&#x3b1; (IFN&#x3b1;) as an active ingredient. Orally administering the composition of the present invention can provide inhibition, alleviation, treatment and prevention for chronic intractable external otitis. According to the present invention, IFN&#x3b1; can give a sufficient effect even when administered in a very small amount.

Therapeutic effect of oral interferon a administration on chronic intractable external otitis

The present invention provides oral compositions which contain interferon &#x3b1; (IFN&#x3b1;) as an active ingredient for preventing and/or treating periodontal disease. The number of causative microorganisms of periodontal disease can be suppressed by administering the compositions into the oral cavity. IFN&#x3b1; of the present invention can produce a sufficient effect even when administered at a very low dose. Furthermore, the compositions of the present invention can also be readily administered to animals such as dogs by formulating them into feed or such.

Oral composition containing interferon-&#x3b1;

Immunity against protozoan is conferred on an animal by a method comprising orally administering to an animal a transformed plant cell comprising a polynucleotide encoding a protective antigen against protozoiasis development, a transformed plant or its progeny or clone comprising the transformed cell, a propagation material of the plant or its progeny or clone, a processed material or extract of the above cell, plant, or its progeny or clone, or propagation material, or a protective antigen against protozoiasis development isolated from the transformed plant cell or the transformed plant or its progeny or clone.

Methods for conferring immunity against protozoans in an animal

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Saitama, Japan

Toru Gotanda