Aktiebolaget Leo

Torsten Rune Perklev

Hans Jacob Fex

Sten Gunnar Veige

Bertil Hogberg

Bo Fredholm

Knut Bertil Hogberg

B Goran Fredholm

This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith. The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3',5'-monophosphate (cyclic AMP). In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.

Novel compounds, compositions containing such compounds, processes for

Method, composition and compounds for treating excess prostaglandins

Secondary phosphoric acid esters, composition and method of use

Novel symmetrical secondary phosphoric acid esters having the general formula ##SPC1## Wherein the substituent R is positioned in meta or para position relative to the phosphoric acid ester group; processes for the preparation of said esters; and compositions containing said esters. The esters are i.a. useful as selective inhibitors of prostaglandins and compounds with prostaglandin activities. They also selectively antagonize the slow reacting substance (SRS).

Medicinal compositions and methods of use involving phosphoric acid

This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith. The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3' ,5'-monophosphate (cyclic AMP). In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.

Secondary phosphoric acid esters

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Helsingborg, Sweden

Torsten Rune Perklev