Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim Pharma Kg

Boehringer Ingelheim International Gmbh

Torsten Kuehn

Burkhard Metzger

Rolf Kuhn

Herbert Wachtel

Hubert Hoelz

Stefan Lustenberger

Heinrich Kladders

Joern-Eric Schulz

Stephan Kurtze

Burkhard Peter Metzger

The invention relates to a powder inhaler with at least one specially sharpened needle, to ensure the precise piercing or cutting open of capsules and hence the optimum delivery of powdered medicament compositions, medicament formulations or medicament mixtures, as well as ensuring that little effort is needed to perforate or cut open the capsule.

Needle for piercing a powder capsule for inhalation

The present invention relates to capsules for housing pharmaceutical preparations for powder inhalers with increased medicinal product safety and capsules for pharmaceutical preparations for powder inhalers with improved adaption to use in powder inhalers. The capsules consist of non-water-soluble, hydrophobic plastics, which themselves do not substantially influence the pharmaceutical quality of the contents, but improve the usability of the filled capsules in respect of their operation, the period of use and/or the geographical location of their use and are advantageous in various steps from manufacture to use.

Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers

An inhaler for inhaling powdered medicaments from capsules, having: a lower part which is cup-shaped, a plate latched to the lower part to close off the lower part, a capsule holder arranged on the underside of the plate, a mouthpiece that can be latched to the top of plate, and an actuating member for interacting with at least one pin for piercing a capsule in the capsule holder, where the actuating member includes a larger outer actuating member and a smaller inner actuating member, the outer actuating member forms a user-operated push-button, the inner actuating member contacts and holds the pin below a suspension element of the outer actuating member from the plate, and the point of application of force by the user onto push-button is lower than the inner actuating member.

Powder inhaler

A process for producing a container comprising an outer container, an inner bag disposed therein and a pressure equalisation opening disposed in the outer container, and a container produced according to this process, is described, wherein a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam being formed. The process forms a pressure equalisation opening in the outer container without endangering the integrity of the container, wherein a lower wastage rate and higher productivity are achieved. To do this, the base seam is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which has a temperature of 40 degrees C. to 70 degrees C., which force breaks open and plastically deforms the base seam so that a pressure equalisation opening is formed in the base area.

Container provided with a pressure equalization opening

A process for the production of a container () comprising an outer container (), an inner bag () disposed therein and a pressure equalisation opening () disposed in the outer container (), and also a container () produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam () being formed. The process is to form a pressure equalisation opening () in the outer container () of the container () without endangering the integrity of the container (), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam () is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40&#xb0; C. to 70&#xb0; C., which force breaks open and plastically deforms the base seam () so that a pressure equalisation opening () is formed in the base area ().

A system for testing systems which are in turn used to test the leaktightness of a hollow body is suggested. Instead of the hollow body, a test body () is placed in the system which generates a defined pressure increase in a measuring chamber () within a pre-determined time span. This defined pressure increase corresponds exactly to the pressure increase generated by a hollow body with a small amount of leakage, wherein the hollow body can still just be regarded as leaktight. The test body can be configured as a glass capillary which extends in a sealing manner between two chambers with different air pressure. Alternatively, the test body can comprise a material which can accept a defined amount of moisture from the ambient atmosphere during storage. A vacuum formed around the test body causes moisture to be withdrawn from the test body and at least partially evaporated in the vacuum, which again leads to an increase in pressure in the chamber. This pressure increase again corresponds to the just-tolerable pressure increase of a hollow body which is to be tested.

Quality control systems for detecting leaks of gaseous or liquid materials from closed containers

A process for the production of a container ( ) comprising an outer container ( ), an inner bag ( ) disposed therein and a pressure equalisation opening ( ) disposed in the outer container ( ), and also a container ( ) produced according to this process, is described, wherein firstly a pre-moulding, comprising two coaxial tubes, is first produced by co-extrusion with the help of a blow mould and with an outwardly-projecting base seam ( ) being formed. The process is to form a pressure equalisation opening ( ) in the outer container ( ) of the container ( ) without endangering the integrity of the container ( ), wherein a lower wastage rate and higher productivity are to be achieved. This is attained by a process wherein the base seam ( ) is partially cut off and a force which acts in the direction of the seam is introduced into the pre-moulding, which still has a temperature of 40&deg; C. to 70&deg;C., which force breaks open and plastically deforms the base seam ( ) so that a pressure equalisation opening ( ) is formed in the base area ( ).

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Appenheim, Germany

Torsten Kuehn