Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Torsten Klockenbring

Rainer Fischer

Stefan Barth

Andreas Reimann

Wolfgang Koch

Rolf Fendel

Fatima Ferreira

Stephanie Kapelski

Gerd Sulz

Dominika Maskus

Michael Stöcker

Gernot Achatz

Michael Huhn

Elke Luger

Carsten Bolwien

Wilhelm Dunkhorst

Michael Stoecker

Hubert LÖDDING

Wolfgang Karl Hofbauer

Katharina Schwarz

Andreas Holländer

Karin Schmitt

Peter Muranyi

Thorsten Sven Rennebarth

Anna Maria Renzl

Björn Seidel

The technology provided herein relates to novel human antibodies againstparasites, in particular against the malaria parasite. The present disclosure pertains to antibodies against apical membrane antigen 1 (AMA-1). These antibodies have high affinity e.g. toschizonts and merozoites, inhibit the reinvasion of merozoites into erythrocytes and thereby neutralize parasitic multiplication.

Anti-plasmodium parasite antibodies

The technology provided herein relates to novel human antibodies againstparasites, in particular against the malaria parasite. The present disclosure pertains to antibodies against merozoite surface protein 10 (MSP10). These antibodies have high affinity e.g. toschizonts and merozoites, inhibit the reinvasion of merozoites into erythrocytes and thereby neutralize parasitic multiplication.

A process is disclosed which enables the establishing of comprehensive immunoglobulin-specific reaction profiles of subjects with disorders of the immune function by the individual V gene repertoire of Ig-expressing B cells. The process comprises the isolation of B cells from body fluids, the isolation of individual B cells and their genetic material, the amplification of nucleic acids coding the variable regions of an antibody expressed by a B cell, the recombinant preparation of antibodies by expressing the amplificates, and the determination of the binding capability of the recombinant antibody to antigens.

Isolation of allergen-specific immunoglobulin genes from human B-cells from atopy sufferers

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Bonn, Germany

Torsten Klockenbring