Societe Des Produits Nestle S.a.

B.r.a.i.n. Biotechnology Research and Information Network Ag

Torsten Ertongur-Fauth

Michael Krohn

Ebenezer Satyaraj

Scott Sherrill

Andreas Hochheimer

Peichuan Sun

George Wells

Juergen Eck

Daniel Meyer

Alexander Pelzer

Delphine Tissot-Favre

Formulations, compositions and products for reducing allergenic Fel d 1 from the environment are disclosed. The formulations include at least one protease that interacts with the Fel d 1 and substantially degrades allergenic epitopes on the Fel d 1. Methods of using the formulations for reducing or eliminating allergenic Fel d 1 from the environment are also disclosed.

Compositions and methods for reducing cat allergens in the environment

Accordingly, the present invention relates to a nucleic acid molecule encoding a protein capable of forming a calcium-activated chloride channel, wherein said nucleic acid molecule comprises or consists of (a) a nucleic acid molecule encoding a protein having the amino acid sequence of SEQ ID NO:1; (b) a nucleic acid molecule having the DNA sequence of SEQ ID NO:2; (c) a nucleic acid molecule having the sequence of SEQ ID NO:2, wherein each thymine is replaced by uracil; (d) a nucleic acid molecule that hybridizes under stringent conditions to the complementary strand of a nucleic acid molecule of (a), (b) or (c); (e) a nucleic acid molecule encoding a protein having at least 97% sequence identity to the protein of (a); or (f) a nucleic acid molecule that is degenerate with respect to the nucleic acid molecule of (b), (c) or (d). The present invention further relates to a protein capable of forming a calcium-activated chloride channel, the use of the nucleic acid molecule of or the protein of the invention for identifying an inhibitor of sweat formation as well as an in vitro method of identifying an inhibitor of sweat formation.

Calcium-activated chloride channel involved in human sweat formation

Growing community of inventors

Darmstadt, Germany

Torsten Ertongur-Fauth