Celgene Corporation

Exelixis, Inc.

Torsten Bernhard Trowe

Gregory D Plowman

Timothy S Heuer

Felix D Karim

Lynn Margaret Bjerke

Candace Swimmer

Ulrike Eisenmann

Gordon Mark Stott

Andreas Michael Vogel

Hinrich Alexander Habeck

Joerg Heinrich Odenthal

Jochen Konrad Scheel

Thomas I Koblizek

Torsten Tilmann Will

Stefan Schulte-Merker

Yinsheng Jin

Provided herein are methods for identifying a cancer patient at risk for resistance to an HDAC inhibitor therapy, comprising obtaining a tumor sample from the cancer patient; detecting the presence of Testis-specific Y-encoded-like protein 5 (TSPYL5) expression in the sample; quantifying a level of the TSPYL5 expression in the sample, wherein a high level of the TSPYL5 expression, relative to a defined expression threshold of the TSPYL5, correlates with resistance to the HDAC inhibitor therapy; and applying the correlation to identify the cancer patient at risk for resistance to the HDAC inhibitor therapy. Also provided is a method for identifying a cancer patient with an increased likelihood of a positive clinical response to an HDAC inhibitor therapy comprising obtaining a tumor sample from the cancer patient; detecting the presence of Testis-specific Y-encoded-like protein 5 (TSPYL5) expression in said sample; quantifying a level of said TSPYL5 expression in said sample, wherein a low level of the TSPYL5 expression, relative to a defined expression threshold of the TSPYL5, identifies said cancer patient with an increased likelihood of a positive clinical response to said HDAC inhibitor therapy. Related methods and compositions are also provided.

Resistance biomarkers for HDAC inhibitors

Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MYLK are provided.

Mylks as modifiers of branching morphogenesis and methods of use

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San Francisco, CA, United States of America

Torsten Bernhard Trowe