Nycomed Imaging As

Nycomed Salutar, Inc.

Amersham Health As

Elementanalys Almen & Gronberg Ab

Torsten Almen

Arne Berg

Jo Klaveness

Klaes Golman

Harald Dugstad

Pal Rongved

Sven Goran Andersson

Lars-Goran Wistrand

Michael Droege

Unni Nordby Wiggen

Tomas Klingstedt

Klaus D Krautwurst

Sook-Hui Kim

Rune Fossheim

Terje Thomassen

Audun N Oksendal

Scott M Rocklage

Mikkel Jacob Thaning

Alan D Watson

Hakan Wikstrom

Frode Rise

Jere D Fellman

Brent Segal

Oyvind Antonsen

Mikkel Jo Slashedrgensen

Hangkan Wikstrom

Shi-bao Yu

Lars Baath

Ib Luenbach

Ib Leunbach

Fredrik Ek

Rolf Servin

Per Jynge

Anna Rydbeck

Arne Aabye

C Allen Chang

Peter Michelsen

S B Yu

O Slashedyvind Antonsen

Ame Berg

Anna Rydeck

Thomas Gronberg

Soren Mattsson

Staffan Sjoberg

Laars BANGANGth

Contrast media

The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula C,R,wherein three non-adjacent R groups are iodine and the remaining R groups are non-ionic, hydrophilic moieties, said compound being water soluble at 20&deg; C. to a concentration of at least 350 mgl/ml and which in aqueous solution at 20&deg; C. at a concentration of 350 mgl/ml has a viscosity no greater than 13.8 mPas.

Iodinated x-ray contrast media

The use in diagnostic imaging, in particular X-ray, MRI, ultrasound and scintigraphy, of contrast agents comprising bismuth clusters and/or organic bismuth compounds, and contrast media containing such bismuth compounds. The bismuth compounds are also useful in therapy, in particular as antimicrobial agents and antiulcer agents. Novel bismuth compounds are also disclosed.

Bismuth compounds

Non-cluster type bismuth compounds

The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C.sub.6 R.sub.5 moeity may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M.sub.1, two or three non-adjacent R groups in each C.sub.6 R.sub.5 moiety being iodine and at least one, and preferably two or three, R groups in each C.sub.6 R.sub.5 moiety being M or M.sub.1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C.sub.6 R.sub.5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M.sub.1 independently represents a C.sub.1-4 alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M.sub.1 moiety; with the proviso that where n is zero either at least one M.sub.1 group other than a hydroxymethyl or 1,2-dihydroxyethyl group is present or then if one hydroxymethyl or 1,2-dihydroxyethyl M.sub.1 group is present at least one nitrogen-attached or hydroxylated-C.sub.3-4 alkyl moiety-containing M group is also present) and isomers thereof.

Iodinated X-ray contrast media

The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein each C.sub.6 R.sub.5 moeity may be the same or different; each R denotes a hydrogen or iodine atom or a group M, two or three non-adjacent R groups on each C.sub.6 R.sub.5 moiety denoting iodine atoms and one, two or three R groups on each C.sub.6 R.sub.5 moiety denoting M groups; X denotes a group providing a 1, 2 or 3 atom chain linking the two C.sub.6 R.sub.5 groups, preferably where X is or contains in the bridging chain a carbonyloxy group each C.sub.6 R.sub.5 group being a triodophenyl group or a group in which each R is other than hydrogen; and each M is independently a non-ionic hydrophilic moiety, M preferably being a non-ionic hydrophilic moiety comprising a monohydroxy- or polyhydroxy-alkyl group) and isomers, especially stereoisomers and rotamers, thereof.

Urea-linked, iodinated bis phenyl compounds for X-ray contrast media

An x-ray contrast medium containing a multinuclear complex of the formula (M.sub.6 (.mu..sub.3 B).sub.8 A.sub.v).sub.x L.sub.w, wherein M is Mo, W, Re Tc, V, Nb, Ta, Ru, or Fe; .mu..sub.3 B represent a tridentate bridging atom; A is a non-bridging atom; L is a ligand coordinately bonded to at least one M atom; x is a positive integer; and v and w are independently zero or positive integers.

Multinuclear complexes for X-ray imaging

The present invention relates to a method of generating an electron spin resonance enhanced magnetic resonance image of a sample which comprises introducing into the sample a magnetic resonance signal enhancing amount of a free radical and generating an enhanced electron spin resonance image of the sample. The method comprises using as the free radical an inert triarylmethyl free radical, wherein each aryl moiety of said triarylmethyl radical, which may be identical or different, comprises an optionally substituted 6-membered carbocyclic or thienyl ring. The invention also relates to the use of trityls in ESR imaging.

Use of free radicals in ESR and ESREMR imaging

Triarylmethyl radicals and the use of inert carbon free radicals in MRI

There are provided chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, said agents being compounds of formula I

Aminopolycarboxylic acids and derivatives thereof

Multinuclear complexes for x-ray imaging

Growing community of inventors

Malmo, Sweden

Torsten Almen