Pharmacia Ab

Torkel Gren

Anders Ringberg

Martin Wikberg

Birgitta Olsson

Lisbeth Nilvebrant

Ulla Hoeck

Helle Kristensen

Lene Orup Jacobsen

Randy J Wald

Bengt Hall&eacute;n

Jan Str&ouml;mbom

Bo Kreilg&aring;rd

A controlled release bead comprises: (i) a core unit of a substantially water-soluble or water-swellable inert material; (ii) a first layer on the core unit of a substantially water-insoluble polymer; (iii) a second layer covering the first layer and containing an active ingredient; and (iv) a third layer of polymer on the second layer effective for controlled release of the active ingredient, wherein the first layer is adapted to control water penetration into the core. A method of producing the controlled release bead is also disclosed.

Controlled release bead, a method of producing the same and multiple unit formulation comprising it

The present invention is drawn to a method of treating an unstable or overactive urinary bladder by treating the patient with tolterodine or a tolterodine-related compound, or pharmaceutically acceptable salt thereof, with a controlled release formulation that maintains a substantially constant serum level of the active moiety or moieties for at least 24 hours. The present invention is further drawn to a formulation for the method.

Therapeutic formulation for administering tolterodine with controlled release

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Kalamazoo, MI, United States of America

Torkel Gren